Title:
PRUSSIAN BLUE/PLURONIC NANOPARTICLE COMPLEX FOR REMOVAL OF REACTIVE OXYGEN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/241966
Kind Code:
A1
Abstract:
The present invention relates to a Prussian blue/pluronic nanoparticle complex for removal of reactive oxygen, and a use thereof. The Prussian blue/pluronic nanoparticle complex according to the present invention exhibits excellent reactive oxygen removal activity and wound healing ability and is stable as well as being superbly biocompatible and, as such, can be effectively used in a pharmaceutical composition, a quasi-drug composition, a cosmetic composition, and a food composition, for use in removing reactive oxygen, and for developing a method for preventing, alleviating, or treating diseases or symptoms caused by excessive generation of reactive oxygen.
Inventors:
CHOI WON IL (KR)
OH HYE RYEON (KR)
LEE JIN SIL (KR)
OH HYE RYEON (KR)
LEE JIN SIL (KR)
Application Number:
PCT/KR2021/006448
Publication Date:
December 02, 2021
Filing Date:
May 24, 2021
Export Citation:
Assignee:
KOREA INST CERAMIC ENG & TECH (KR)
International Classes:
A61K47/69; A61K8/19; A61K8/84; A61K33/26; A61P9/10; A61P17/02; A61P25/28; A61P39/06; A61Q19/00; A61Q19/08
Foreign References:
| KR20170043862A | 2017-04-24 |
Other References:
FU JIJUN, WU BO, WEI MINYAN, HUANG YUGANG, ZHOU YI, ZHANG QIANG, DU LINGRAN: "Prussian blue nanosphere-embedded in situ hydrogel for photothermal therapy by peritumoral administration", ACTA PHARMACEUTICA SINICA B, vol. 9, no. 3, 1 May 2019 (2019-05-01), pages 604 - 614, XP055871522, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2018.12.005
HYERYEON OH, JIN SIL LEE, DAEKYUNG SUNG, JIN HYUNG LEE, SANG HYUN MOH, JONG-MIN LIM , WON IL CHOI: "Synergistic antioxidant activity of size controllable chitosan-templated Prussian blue nanoparticle", NANOMEDICINE, vol. 14, no. 19, 1 January 2019 (2019-01-01), GB , pages 2567 - 2578, XP009532171, ISSN: 1743-5889, DOI: 10.2217/nnm-2019-0223
ZHANG WEI, HU SUNLING, YIN JUN-JIE, HE WEIWEI, LU WEI, MA MING, GU NING, ZHANG YU: "Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 18, 26 February 2016 (2016-02-26), pages 5860 - 5865, XP055871524, ISSN: 0002-7863, DOI: 10.1021/jacs.5b12070
ZHAO JIULONG, CAI XIAOJUN, GAO WEI, ZHANG LINLIN, ZOU DUOWU, ZHENG YUANYI, LI ZHAOSHEN, CHEN HANGRONG: "Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice", APPLIED MATERIALS & INTERFACES, vol. 10, no. 31, 8 August 2018 (2018-08-08), US, pages 26108 - 26117, XP055871536, ISSN: 1944-8244, DOI: 10.1021/acsami.8b10345
HYERYEON OH, JIN SIL LEE, DAEKYUNG SUNG, JIN HYUNG LEE, SANG HYUN MOH, JONG-MIN LIM , WON IL CHOI: "Synergistic antioxidant activity of size controllable chitosan-templated Prussian blue nanoparticle", NANOMEDICINE, vol. 14, no. 19, 1 January 2019 (2019-01-01), GB , pages 2567 - 2578, XP009532171, ISSN: 1743-5889, DOI: 10.2217/nnm-2019-0223
ZHANG WEI, HU SUNLING, YIN JUN-JIE, HE WEIWEI, LU WEI, MA MING, GU NING, ZHANG YU: "Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 18, 26 February 2016 (2016-02-26), pages 5860 - 5865, XP055871524, ISSN: 0002-7863, DOI: 10.1021/jacs.5b12070
ZHAO JIULONG, CAI XIAOJUN, GAO WEI, ZHANG LINLIN, ZOU DUOWU, ZHENG YUANYI, LI ZHAOSHEN, CHEN HANGRONG: "Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice", APPLIED MATERIALS & INTERFACES, vol. 10, no. 31, 8 August 2018 (2018-08-08), US, pages 26108 - 26117, XP055871536, ISSN: 1944-8244, DOI: 10.1021/acsami.8b10345
Attorney, Agent or Firm:
WETHEPEOPLE IP & LAW FIRM (KR)
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