Title:
PURIFICATION METHOD OF ANTIBODY COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/239704
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for eliminating a glycosylation isomer from an antibody drug, etc. The present invention provides, for example, a purification method of an antibody composition, said purification method comprising loading the antibody composition on a conventional chromatography so as to allow the chromatography support to adsorb an antibody which has no sugar chain attached to a site other than the Fc region glycosylation consensus region, eluting the support with an elution solvent and thus eluting the antibody adsorbed on the support to thereby give a purified antibody composition.
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Inventors:
YOSHIMORI TAKAYUKI (JP)
IARUSSO STEFAN (DE)
IARUSSO STEFAN (DE)
Application Number:
PCT/JP2022/019548
Publication Date:
November 17, 2022
Filing Date:
May 06, 2022
Export Citation:
Assignee:
CHIOME BIOSCIENCE INC (JP)
International Classes:
C07K1/16; C07K16/18; C07K17/04; C12N15/13
Domestic Patent References:
| WO2014054820A1 | 2014-04-10 | |||
| WO2020182984A2 | 2020-09-17 | |||
| WO2020153390A1 | 2020-07-30 | |||
| WO2008120801A1 | 2008-10-09 | |||
| WO2005100379A1 | 2005-10-27 | |||
| WO2014054820A1 | 2014-04-10 |
Foreign References:
| JP2016512848A | 2016-05-09 | |||
| JP2001064300A | 2001-03-13 | |||
| JP2021079977A | 2021-05-27 | |||
| JPS644947A | 1989-01-10 |
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KABAT ET AL.: "Sequences of Proteins of Immunological Interests", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, pages: 91 - 3242
BULL. NATL. INST. HEALTH SCI., vol. 132, 2014, pages 36 - 46
CHROMATOGRAPHY, vol. 34, no. 2, 2013, pages 83 - 88
PROTEIN CELL, vol. 9, 2018, pages 63 - 73
FRONT. IMMUNOL., vol. 8, no. 646, 2017, pages 1 - 8
J. BIOL. CHEM., vol. 284, no. 47, 2009, pages 32493 - 32506
EMBO J., vol. 10, 1991, pages 2717 - 2723
J. IMMUNOL., vol. 196, 2016, pages 1435 - 1441
ANAL. BIOCHEM., vol. 349, 2006, pages 197 - 207
NATURE REVIEW IMMUNOLOGY, 4 February 2019 (2019-02-04)
BIOCHEM. J., vol. 338, no. 2, 1999, pages 529 - 538
MABS, vol. 6, no. 4, 2014, pages 852 - 858
J. PHARM. BIOMED. ANAL., vol. 130, 2016, pages 3 - 18
J. BIOL. CHEM., vol. 285, no. 21, 2010, pages 16012 - 22
ONCOTARGET, vol. 7, no. 21, 2016, pages 31166 - 76
J. IMMUNOL. METHODS, vol. 467, 2019, pages 58 - 62
PALSSON ET AL., NATURE BIOTECHNOLOGY, vol. 31, no. 8, 2013, pages 759 - 765
NATURE, vol. 580, no. 16, 2020, pages 330 - 338
KABAT ET AL.: "Sequences of Proteins of Immunological Interests", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, pages: 91 - 3242
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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