PYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF

WIPO Patent Application WO/2004/014932

A1

A pyrazole derivative represented by the general formula (I) (wherein R¹ is H, optionally substituted C_1-6 alkyl, etc.; either of Q and T is the group of the formula (II) or the formula (III) and the other is optionally substituted C_1-6 alkyl, etc.; R² is H, halogeno, OH, optionally substituted C_1-6 alkyl, etc.; X is a single bond, O, or S; Y is a single bond, C_1-6 alkylene, etc.; Z is CO or SO₂; R⁴ and R⁵ each is H, optionally substituted C_1-6 alkyl, etc.; and R³, R⁶, and R⁷ each is H, halogeno, etc.), a pharmacologically acceptable salt of the derivative, or a prodrug of either. They have excellent human SGLT1 inhibitory activity and are useful as a preventive or therapeutic agent for diseases attributable to hyperglycemia such as diabetes, complications of diabetes, and obesity.

TERANISHI HIROTAKA (JP)
FUSHIMI NOBUHIKO (JP)
YONEKUBO SHIGERU (JP)
SHIMIZU KAZUO (JP)
SHIBAZAKI TOSHIHIDE (JP)
ISAJI MASAYUKI (JP)

PCT/JP2003/010048

February 19, 2004

August 07, 2003

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KISSEI PHARMACEUTICAL (JP)
TERANISHI HIROTAKA (JP)
FUSHIMI NOBUHIKO (JP)
YONEKUBO SHIGERU (JP)
SHIMIZU KAZUO (JP)
SHIBAZAKI TOSHIHIDE (JP)
ISAJI MASAYUKI (JP)

A61P3/04; A61P3/06; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00; C07H17/02; (IPC1-7): C07H17/02; A61K31/7056; A61P3/04; A61P3/06; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00

WO2001016147A1	2001-03-08
WO2000059889A1	2000-10-12
WO1999010010A1	1999-03-04
WO1999026606A2	1999-06-03

US5274111A	1993-12-28
JP2001002567A	2001-01-09

See also references of EP 1544208A4

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