Title:
PYRAZOLE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2023/098439
Kind Code:
A1
Abstract:
A pyrazole derivative, and a preparation method therefor and a use thereof in medicine. In particular, the present invention relates to a PRMT5 inhibitor having a structure shown in formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use thereof as a PRMT5 inhibitor, and a use thereof in treatment and/or prevention of a PRMT5-mediated disease.
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Inventors:
DENG HAIBING (CN)
YANG FEI (CN)
ZHU WEI (CN)
LIU XIAOFENG (CN)
LIU JIAN (CN)
LI MINGFENG (CN)
LIU ZHAOMIN (CN)
YING HAIYAN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
YANG FEI (CN)
ZHU WEI (CN)
LIU XIAOFENG (CN)
LIU JIAN (CN)
LI MINGFENG (CN)
LIU ZHAOMIN (CN)
YING HAIYAN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2022/130953
Publication Date:
June 08, 2023
Filing Date:
November 09, 2022
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07D237/32; A61K31/502; A61K31/517; A61K31/519; A61P35/00; C07D401/04; C07D401/14; C07D471/04; C07D471/14; C07D487/04; C07D498/04
Domestic Patent References:
| WO2022192745A1 | 2022-09-15 | |||
| WO2022216645A1 | 2022-10-13 | |||
| WO2022216648A1 | 2022-10-13 | |||
| WO2021050915A1 | 2021-03-18 | |||
| WO2017153518A1 | 2017-09-14 |
Foreign References:
| CN101282960A | 2008-10-08 |
Other References:
ACHMATOWICZ MICHAL M, CHEN CHENG-YI, SNEAD DAVID R: "Simultaneous Processing of Antagonistic Chemical Events (SPACE): An Atroposelective Dynamic Kinetic Resolution of MRTX1719", CHEMRXIV, 20 June 2022 (2022-06-20), pages 1 - 4, XP093009436, Retrieved from the Internet [retrieved on 20221219], DOI: 10.26434/chemrxiv-2022-pwtdx-v2
KULYK SVITLANA, DE PAUL SUSAN M., MARX MATTHEW A., PEAKMAN TORREN M., SMITH CHRISTOPHER R.: "Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19 F NMR Spectroscopy", ACS OMEGA, ACS PUBLICATIONS, US, vol. 7, no. 36, 13 September 2022 (2022-09-13), US , pages 32062 - 32067, XP093009433, ISSN: 2470-1343, DOI: 10.1021/acsomega.2c03316
KULYK SVITLANA, DE PAUL SUSAN M., MARX MATTHEW A., PEAKMAN TORREN M., SMITH CHRISTOPHER R.: "Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19 F NMR Spectroscopy", ACS OMEGA, ACS PUBLICATIONS, US, vol. 7, no. 36, 13 September 2022 (2022-09-13), US , pages 32062 - 32067, XP093009433, ISSN: 2470-1343, DOI: 10.1021/acsomega.2c03316
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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