Title:
PYRIDOPYRIMIDINONE COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/155716
Kind Code:
A1
Abstract:
Provided are a pyridopyrimidinone compound having a structure shown in general formula (II) and an application thereof. The compound can effectively inhibit KRAS G12C mutation, has the potential to be a drug for treating malignant tumors carrying KRAS G12C mutation (especially, non-small cell lung cancer (NSCLC) and colorectal cancer), and has great application value.
Inventors:
CAI XIONG (CN)
WENG YUNWO (CN)
QING YUANHUI (CN)
LIN MINGSHENG (CN)
LIU BIN (CN)
HE QIJIE (CN)
LIU YITING (CN)
FENG QIAO (CN)
FAN FUSHUN (CN)
QIAN CHANGGENG (CN)
WENG YUNWO (CN)
QING YUANHUI (CN)
LIN MINGSHENG (CN)
LIU BIN (CN)
HE QIJIE (CN)
LIU YITING (CN)
FENG QIAO (CN)
FAN FUSHUN (CN)
QIAN CHANGGENG (CN)
Application Number:
PCT/CN2020/136848
Publication Date:
August 12, 2021
Filing Date:
December 16, 2020
Export Citation:
Assignee:
GUANGZHOU BEBETTER MEDICINE TECH CO LTD (CN)
International Classes:
C07D471/04; A61K31/519; A61P35/00
Domestic Patent References:
| WO2018217651A1 | 2018-11-29 | |||
| WO2019213516A1 | 2019-11-07 | |||
| WO2020233592A1 | 2020-11-26 | |||
| WO2020239077A1 | 2020-12-03 |
Foreign References:
| CN110366550A | 2019-10-22 | |||
| US20190374542A1 | 2019-12-12 | |||
| US20200055845A1 | 2020-02-20 | |||
| US20200069657A1 | 2020-03-05 | |||
| US20180334454A1 | 2018-11-22 |
Other References:
CELL, vol. 170, 2017, pages 17 - 33
CELL, vol. 74, 1993, pages 205 - 214
NATURE, vol. 370, 1994, pages 527 - 532
EMBO J, vol. 15, 1996, pages 5256 - 5267
NATURE, vol. 575, 2019, pages 217 - 223
NAT. REV. DRUG DISCOV, vol. 13, 2014, pages 828 - 851
NAT REV DRUG DISCOV, vol. 15, 2016, pages 771 - 785
BERG ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
J MASS SPECTROM, vol. 35, 2000, pages 71 - 76
See also references of EP 4101852A4
CELL, vol. 74, 1993, pages 205 - 214
NATURE, vol. 370, 1994, pages 527 - 532
EMBO J, vol. 15, 1996, pages 5256 - 5267
NATURE, vol. 575, 2019, pages 217 - 223
NAT. REV. DRUG DISCOV, vol. 13, 2014, pages 828 - 851
NAT REV DRUG DISCOV, vol. 15, 2016, pages 771 - 785
BERG ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
J MASS SPECTROM, vol. 35, 2000, pages 71 - 76
See also references of EP 4101852A4
Attorney, Agent or Firm:
GUANGZHOU PRIME IP LAW OFFICE (CN)
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