Title:
PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO2005095357
Kind Code:
A3
Abstract:
The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.
Inventors:
SEKIGUCHI YOSHINORI (JP)
KANUMA KOSUKE (JP)
OMODERA KATSUNORI (JP)
TRAN THUY-ANH (US)
SEMPLE GRAEME (US)
KRAMER BRYAN A (US)
KANUMA KOSUKE (JP)
OMODERA KATSUNORI (JP)
TRAN THUY-ANH (US)
SEMPLE GRAEME (US)
KRAMER BRYAN A (US)
Application Number:
PCT/JP2005/006582
Publication Date:
January 19, 2006
Filing Date:
March 29, 2005
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
ARENA PHARM INC (US)
SEKIGUCHI YOSHINORI (JP)
KANUMA KOSUKE (JP)
OMODERA KATSUNORI (JP)
TRAN THUY-ANH (US)
SEMPLE GRAEME (US)
KRAMER BRYAN A (US)
ARENA PHARM INC (US)
SEKIGUCHI YOSHINORI (JP)
KANUMA KOSUKE (JP)
OMODERA KATSUNORI (JP)
TRAN THUY-ANH (US)
SEMPLE GRAEME (US)
KRAMER BRYAN A (US)
International Classes:
C07D239/48; A61K31/505; A61P3/04; A61P3/10; C07D239/00; C07D239/42; C07D239/545; C07D401/12; C07D403/04; C07D403/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D473/34; C07D487/04; C07D239/54
Domestic Patent References:
| WO2004067516A1 | 2004-08-12 | |||
| WO1999065908A1 | 1999-12-23 | |||
| WO1995031441A1 | 1995-11-23 | |||
| WO1996006086A1 | 1996-02-29 | |||
| WO2003070244A1 | 2003-08-28 | |||
| WO2003028641A2 | 2003-04-10 | |||
| WO2004087680A1 | 2004-10-14 | |||
| WO1997020823A2 | 1997-06-12 | |||
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Foreign References:
| US20030229119A1 | 2003-12-11 | |||
| EP1464335A2 | 2004-10-06 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 2003, no. 12 5 December 2003 (2003-12-05)
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