Title:
PYRROLOQUINOLINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2000/006571
Kind Code:
A1
Abstract:
Pyrroloquinoline derivatives having tachykinin antagonism, in particular, substance P receptor antagonism. Namely, pyrroloquinoline derivatives represented by general formula (1) and salts thereof and medicinal compositions containing these compounds or pharmaceutically useful salts thereof, wherein R?1¿, R?2¿ and R?3¿ are the same or different and each represents hydrogen or C¿1-6? alkyl; the ring A is a homocycle or a heterocycle optionally having 1 to 3 substituents selected independently (wherein 2 substituents adjacent to each other may be bonded together to form a ring); the ring B is a benzene ring optionally having 1 to 5 substituents (wherein 2 substituents adjacent to each other may be bonded together to form a ring); and the ring C is a benzene ring optionally having 1 to 3 substituents (wherein 2 substituents adjacent to each other may be bonded together to form a ring).
Inventors:
FUKUDA YASUMICHI (JP)
TANIOKA ASAO (JP)
TANIOKA ASAO (JP)
Application Number:
PCT/JP1999/004034
Publication Date:
February 10, 2000
Filing Date:
July 28, 1999
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
FUKUDA YASUMICHI (JP)
TANIOKA ASAO (JP)
FUKUDA YASUMICHI (JP)
TANIOKA ASAO (JP)
International Classes:
A61K31/435; A61P1/00; A61P1/04; A61P1/08; A61P11/00; A61P13/02; A61P15/00; A61P25/04; A61P29/00; A61P43/00; C07D471/06; (IPC1-7): C07D471/06; A61K31/47
Domestic Patent References:
| WO1992018483A1 | 1992-10-29 |
Foreign References:
| EP0059698A1 | 1982-09-08 |
Other References:
KAPPE THOMAS: "Methanetricarboxylates as key reagents for the simple preparation of heteroarylcarboxamides with potential biological activity. Part 1 Reaction of methanetricarboxylates with indoline and 1,2,3,4-tetrahydroquinoline", J. HETEROCYCL. CHEM., vol. 34, no. 3, May 1997 (1997-05-01) - June 1997 (1997-06-01), pages 969 - 972, XP002925187
Attorney, Agent or Firm:
Minoura, Kiyoshi (Kudankita 3-chome Chiyoda-ku Tokyo, JP)
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