Title:
QUINAZOLINE COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/237903
Kind Code:
A1
Abstract:
Provided are a quinazoline compound and an application thereof. Specifically provided is a quinazoline compound as shown in formula I. The compound is novel in structure and has a good inhibitory effect on cell factors TNF-α, IL-6, and IL-1β.
Inventors:
WANG YUJI (CN)
DU LISHA (CN)
XIA GUANGXIN (CN)
ZHAO FEI (CN)
LI GONGSHENG (CN)
HAO LIJUN (CN)
WU YICHEN (CN)
KE YING (CN)
DU LISHA (CN)
XIA GUANGXIN (CN)
ZHAO FEI (CN)
LI GONGSHENG (CN)
HAO LIJUN (CN)
WU YICHEN (CN)
KE YING (CN)
Application Number:
PCT/CN2022/092860
Publication Date:
November 17, 2022
Filing Date:
May 13, 2022
Export Citation:
Assignee:
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D215/46; A61K31/4155; A61K31/4166; A61K31/421; A61K31/4706; A61K31/496; A61K31/5375; A61P31/14; A61P31/18; A61P31/20; A61P37/02; C07D231/12; C07D233/76; C07D241/12; C07D269/02; C07D295/02
Foreign References:
CN112457244A | 2021-03-09 | |||
CN202110530276A | 2021-05-14 |
Other References:
DATABASE REGISTRY 7 October 2020 (2020-10-07), ANONYMOUS : "-Ethanol, 2-[[6-[(7-chloro-4-quinolinyl)amino]heptyl]ethylamino]- (CA INDEX NAME) ", XP093003234, retrieved from STN Database accession no. 2489438-21-1
JANG C.-H., CHOI J.-H., BYUN M.-S., JUE D.-M.: "Chloroquine inhibits production of TNF-α, IL-1β and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes", RHEUMATOLOGY, OXFORD UNIVERSITY PRESS, LONDON, GB, vol. 45, no. 6, 1 June 2006 (2006-06-01), GB , pages 703 - 710, XP093003461, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kei282
NISHA, GUT JIRI, ROSENTHAL PHILIP J., KUMAR VIPAN: "β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 84, 1 September 2014 (2014-09-01), AMSTERDAM, NL , pages 566 - 573, XP093003463, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.07.064
DEVI KAVITA, YUMNA ASMAT, PARUL SAHI, SWAPNIL SHARMA, JAYA DWIVEDI: "Synthesis and Antimicrobial Studies of Oxazolidinone Derivatives", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH, GLOBAL RESEARCH ONLINE PUBLISHING HOUSE, IN, vol. 14, no. 2, 31 December 2012 (2012-12-31), IN , pages 124 - 129, XP093003471, ISSN: 0976-044X
"Pharmacopoeia of the People's Republic of China", 2020
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2009
JANG C.-H., CHOI J.-H., BYUN M.-S., JUE D.-M.: "Chloroquine inhibits production of TNF-α, IL-1β and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes", RHEUMATOLOGY, OXFORD UNIVERSITY PRESS, LONDON, GB, vol. 45, no. 6, 1 June 2006 (2006-06-01), GB , pages 703 - 710, XP093003461, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kei282
NISHA, GUT JIRI, ROSENTHAL PHILIP J., KUMAR VIPAN: "β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 84, 1 September 2014 (2014-09-01), AMSTERDAM, NL , pages 566 - 573, XP093003463, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.07.064
DEVI KAVITA, YUMNA ASMAT, PARUL SAHI, SWAPNIL SHARMA, JAYA DWIVEDI: "Synthesis and Antimicrobial Studies of Oxazolidinone Derivatives", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH, GLOBAL RESEARCH ONLINE PUBLISHING HOUSE, IN, vol. 14, no. 2, 31 December 2012 (2012-12-31), IN , pages 124 - 129, XP093003471, ISSN: 0976-044X
"Pharmacopoeia of the People's Republic of China", 2020
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2009
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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