Title:
QUINOXALINE COMPOUND AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/046149
Kind Code:
A1
Abstract:
Disclosed in the present invention are a quinoxaline compound, an isomer, a solvate, a deuterated derivative, or a pharmaceutically acceptable salt of the compound. R1, R2, R3, R4, R5, and n are defined in detail in the description. In addition, also disclosed in the present invention are a drug which uses the compound, the isomer, the solvate, the deuterated derivative, and the salt of the compound as active ingredients, and a use thereof in the treatment of diseases related to PARP-1, such as cancer.
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Inventors:
ZHANG WENYAN (CN)
Application Number:
PCT/CN2022/121260
Publication Date:
March 30, 2023
Filing Date:
September 26, 2022
Export Citation:
Assignee:
ZHANG WENYAN (CN)
International Classes:
C07D401/14; A61K31/496; A61P35/00
Domestic Patent References:
| WO2022222921A1 | 2022-10-27 | |||
| WO2021013735A1 | 2021-01-28 | |||
| WO2021260092A1 | 2021-12-30 | |||
| WO2010111626A2 | 2010-09-30 | |||
| WO2009053373A1 | 2009-04-30 |
Foreign References:
| CN102341394A | 2012-02-01 |
Other References:
JOHANNES JEFFREY W., BALAZS AMBER, BARRATT DEREK, BISTA MICHAL, CHUBA MATTHEW D., COSULICH SABINA, CRITCHLOW SUSAN E., DEGORCE SÉB: "Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 19, 14 October 2021 (2021-10-14), US , pages 14498 - 14512, XP093028792, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01012
Attorney, Agent or Firm:
JJS INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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