Title:
RADIOACTIVE METAL COMPLEX AND METHOD FOR PRODUCING SAME, AND RADIOACTIVE METAL SCAVENGER
Document Type and Number:
WIPO Patent Application WO/2022/176954
Kind Code:
A1
Abstract:
Disclosed is a radioactive metal complex. The radioactive metal complex has a radioactive metal element and a ligand derived from a compound represented by formula (1). The radioactive metal element is 89Zr or 225Ac. (1) [In formula (1), n represents an integer of 0-3. Q1, Q2, Q3, Q4 each represent a group selected from collection A, a group selected from collection B, a group represented by formula (C1), or the like. At least one of Q1, Q2, Q3, and Q4 is a group selected from collection A. Among Q1, Q2, Q3, and Q4, the number of groups represented by formula (B3) in collection B is 0-2. Collection A comprises groups and the like represented by formula (A1). (A1) Collection B comprises groups represented by formula (B1), groups represented by formula (B3), and the like. (B1) (B3) Z1, Z2, Z3, and Z4 each represent a divalent linkage group. R represents a divalent linkage group.]
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Inventors:
KOBAYASHI NORIFUMI (JP)
KOSHINO NOBUYOSHI (JP)
IMAI TOMOYUKI (JP)
KISHIMOTO SATOSHI (JP)
IZAWA AKIHIRO (JP)
KOSHINO NOBUYOSHI (JP)
IMAI TOMOYUKI (JP)
KISHIMOTO SATOSHI (JP)
IZAWA AKIHIRO (JP)
Application Number:
PCT/JP2022/006430
Publication Date:
August 25, 2022
Filing Date:
February 17, 2022
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
NIHON MEDIPHYSICS CO LTD (JP)
NIHON MEDIPHYSICS CO LTD (JP)
International Classes:
C07F7/00; A61K51/04; C07D401/14; C07F5/00
Domestic Patent References:
| WO2019232294A1 | 2019-12-05 | |||
| WO2015153772A2 | 2015-10-08 |
Foreign References:
| JPH01113349A | 1989-05-02 | |||
| JP2013515744A | 2013-05-09 | |||
| US5294717A | 1994-03-15 | |||
| JP2020515596A | 2020-05-28 |
Other References:
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EDMONDS SCOTT, VOLPE ALESSIA, SHMEEDA HILARY, PARENTE-PEREIRA ANA C., RADIA RIYA, BAGUÑA-TORRES JULIA, SZANDA ISTVAN, SEVERIN GREG: "Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines", ACS NANO, vol. 10, no. 11, 22 November 2016 (2016-11-22), US , pages 10294 - 10307, XP055960212, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b05935
SANDRA HESKAMP; RENÉ RAAVÉ; OTTO BOERMAN; MARK RIJPKEMA; VICTOR GONCALVES; FRANCK DENAT: "89 Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89 Zr Radiochemistry", BIOCONJUGATE CHEMISTRY, vol. 28, no. 9, 20 September 2017 (2017-09-20), US , pages 2211 - 2223, XP055734862, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00325
ERIC W. PRICE, CHRIS ORVIG: "Matching chelators to radiometals for radiopharmaceuticals", CHEMICAL SOCIETY REVIEWS, vol. 43, no. 1, 7 January 2014 (2014-01-07), UK , pages 260 - 290, XP055397567, ISSN: 0306-0012, DOI: 10.1039/C3CS60304K
WANG XIAOZHU, JARAQUEMADA-PELÁEZ MARÍA DE GUADALUPE, CAO YANG, PAN JINHE, LIN KUO-SHYAN, PATRICK BRIAN O., ORVIG CHRIS: "H 2 hox: Dual-Channel Oxine-Derived Acyclic Chelating Ligand for 68 Ga Radiopharmaceuticals", INORGANIC CHEMISTRY, vol. 58, no. 4, 18 February 2019 (2019-02-18), Easton , US , pages 2275 - 2285, XP055960209, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.8b01208
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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