Title:
LIPID NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2022/176953
Kind Code:
A1
Abstract:
The present invention provides a lipid nanoparticle and the like containing a pH-sensitive cationic lipid represented by formula (1) [in formula (1), R1 and R2 are each independently a straight-chain C10-14 alkyl group, a straight-chain C10-20 alkenyl group having one or two unsaturated bonds, or -CH(R5)(R6)(where R5 and R6 are each independently a straight-chain C5-10 alkyl group); p represents an integer of 3-8; and R3 and R4 are each independently a methyl group or an ethyl group].
Inventors:
NAKAMURA TAKASHI (JP)
HARASHIMA HIDEYOSHI (JP)
SATO YUSUKE (JP)
YAMADA KOHARU (JP)
NAKADE TAISEI (JP)
HARASHIMA HIDEYOSHI (JP)
SATO YUSUKE (JP)
YAMADA KOHARU (JP)
NAKADE TAISEI (JP)
Application Number:
PCT/JP2022/006427
Publication Date:
August 25, 2022
Filing Date:
February 17, 2022
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K47/18; A61K9/14; A61K31/7088; A61K31/713; A61K47/10; A61K47/28; A61K48/00; C12N15/11; C12N15/113
Domestic Patent References:
| WO2020252375A1 | 2020-12-17 | |||
| WO2019131770A1 | 2019-07-04 | |||
| WO2018230710A1 | 2018-12-20 |
Other References:
SATO YUSUKE; HASHIBA KAZUKI; SASAKI KOSUKE; MAEKI MASATOSHI; TOKESHI MANABU; HARASHIMA HIDEYOSHI: "Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAsin vivo", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 295, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 140 - 152, XP085589363, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.01.001
NAKAMURA TAKASHI; NAKADE TAISEI; YAMADA KOHARU; SATO YUSUKE; HARASHIMA HIDEYOSHI: "The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 609, 27 September 2021 (2021-09-27), NL , XP086850950, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2021.121140
NAKAMURA TAKASHI; NAKADE TAISEI; YAMADA KOHARU; SATO YUSUKE; HARASHIMA HIDEYOSHI: "The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 609, 27 September 2021 (2021-09-27), NL , XP086850950, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2021.121140
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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