Title:
RAS MUTANT EPITOPE PEPTIDE AND T CELL RECEPTOR RECOGNIZING RAS MUTANT
Document Type and Number:
WIPO Patent Application WO/2022/111451
Kind Code:
A1
Abstract:
The present invention relates to the field of immunology and tumor treatment. Specifically, an Ras G12V mutant epitope peptide, an antigen presenting cell expressing the epitope peptide, a tumor vaccine containing same, and a use of the tumor vaccine in preventing or treating a tumor having RAS G12V mutation. The present invention further relates to a T cell receptor (TCR) specifically recognizing an Ras G12V mutant, a conjugate and a fusion protein containing the TCR, an immune cell expressing the TCR, a T cell drug containing same, and a use of the T cell drug in preventing or treating a tumor having RAS G12V mutation.
Inventors:
MOU NAN (CN)
YU YUE (CN)
YUAN JIJUN (CN)
YU YUE (CN)
YUAN JIJUN (CN)
Application Number:
PCT/CN2021/132337
Publication Date:
June 02, 2022
Filing Date:
November 23, 2021
Export Citation:
Assignee:
SHANGHAI GENBASE BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K14/82; A61K35/17; A61K39/00; A61P35/00; C07K14/725
Domestic Patent References:
| WO2021173902A1 | 2021-09-02 | |||
| WO2019246286A1 | 2019-12-26 | |||
| WO2020089433A2 | 2020-05-07 | |||
| WO2003020763A2 | 2003-03-13 | |||
| WO2004033685A1 | 2004-04-22 | |||
| WO2011044186A1 | 2011-04-14 |
Foreign References:
| CN106414493A | 2017-02-15 | |||
| CN111201237A | 2020-05-26 | |||
| CN108395479A | 2018-08-14 | |||
| CN110856751A | 2020-03-03 | |||
| US8361794B2 | 2013-01-29 | |||
| US8906383B2 | 2014-12-09 |
Other References:
DATABASE Peptide 05/06/2016, ANONYMOUS : "T-Cell Receptor Alpha Chain Variable Region, Partial [Homo Sapiens]", XP055932677, retrieved from NCBI Database accession no. ANO56466
QIONG JW ET AL., KRAS G12V, pages 7 - 16
LEFRANCLEFRANC: "T cell receptor facts book", 2001, ACADEMIC PRESS
LEFRANC, THE IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC ET AL., NUCLEIC ACIDS RES, vol. 27, 1999, pages 209 - 212
LEFRANC ET AL., DEV COMP IMMUNOL, vol. 27, no. 1, 2003, pages 55 - 77
MALMQVIST M, NATURE, vol. 361, 1993, pages 186 - 187
DAVIES ET AL., ANNUAL REV BIOCHEM, vol. 59, 1990, pages 439 - 473
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
BRUMMELL ET AL., BIOCHEM., vol. 32, 1993, pages 1180 - 1187
KOBAYASHI ET AL., PROTEIN ENG., vol. 12, no. 10, 1999, pages 879 - 884
BURKS ET AL., PROC. NATL ACAD. SET USA, vol. 94, 1997, pages 412 - 417
"Immunology-A Synthesis", 1991, SINAUER ASSOCIATES
F. M. AUSUBEL ET AL.: "Short protocols in Molecular Biology", 1995, JOHN WILEY & SONS, INC.
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
QIONG JW ET AL., KRAS G12V, pages 7 - 16
LEFRANCLEFRANC: "T cell receptor facts book", 2001, ACADEMIC PRESS
LEFRANC, THE IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC ET AL., NUCLEIC ACIDS RES, vol. 27, 1999, pages 209 - 212
LEFRANC ET AL., DEV COMP IMMUNOL, vol. 27, no. 1, 2003, pages 55 - 77
MALMQVIST M, NATURE, vol. 361, 1993, pages 186 - 187
DAVIES ET AL., ANNUAL REV BIOCHEM, vol. 59, 1990, pages 439 - 473
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
BRUMMELL ET AL., BIOCHEM., vol. 32, 1993, pages 1180 - 1187
KOBAYASHI ET AL., PROTEIN ENG., vol. 12, no. 10, 1999, pages 879 - 884
BURKS ET AL., PROC. NATL ACAD. SET USA, vol. 94, 1997, pages 412 - 417
"Immunology-A Synthesis", 1991, SINAUER ASSOCIATES
F. M. AUSUBEL ET AL.: "Short protocols in Molecular Biology", 1995, JOHN WILEY & SONS, INC.
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF:
Previous Patent: BRICK MAKING SYSTEM, PRODUCTION CONTROL METHOD AND APPARATUS, SYSTEM, PRODUCTION DEVICE, AND MEDIUM
Next Patent: PORTABLE FAN
Next Patent: PORTABLE FAN