Title:
RECOMBINANT MICROORGANISM FOR PRODUCING S-METHYLMETHIONINE, AND METHOD FOR PREPARING S-METHYLMETHIONINE USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/055056
Kind Code:
A1
Abstract:
The present invention relates to a recombinant microorganism having the ability to produce S-methylmethionine (SMM) by overexpressing a gene that encodes methionine S-methylmethionine transferase (MMT) in a microorganism having glycolysis and S-adenosylmethionine (SAM) biosynthetic pathway processes, and a method for producing SMM using the recombinant microorganism. According to the present invention, S-methylmethionine can be produced with excellent yield through microbial biosynthesis, unlike conventional plant extraction or chemical synthesis, and this is expected to be usable as a core technology for S-methylmethionine production.
Inventors:
OH MIN-KYU (KR)
LEE JUN-MIN (KR)
PARK BU-SOO (KR)
PARK MIN-HO (KR)
LEE JUN-MIN (KR)
PARK BU-SOO (KR)
PARK MIN-HO (KR)
Application Number:
PCT/KR2021/002981
Publication Date:
March 17, 2022
Filing Date:
March 10, 2021
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C12N15/70; C12N9/06; C12N9/10; C12N15/75; C12N15/76; C12N15/81
Domestic Patent References:
| WO2000049157A2 | 2000-08-24 |
Foreign References:
| KR101784633B1 | 2017-10-17 | |||
| KR20180093981A | 2018-08-22 |
Other References:
KOCSIS MICHAEL G., RANOCHA PHILIPPE, GAGE DOUGLAS A., SIMON ERIC S., RHODES DAVID, PEEL GREGORY J., MELLEMA STEFAN, SAITO KAZUKI, : "Insertional Inactivation of the Methionine S -Methyltransferase Gene Eliminates the S -Methylmethionine Cycle and Increases the Methylation Ratio", PLANT PHYSIOLOGY, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, USA, vol. 131, no. 4, 1 April 2003 (2003-04-01), Rockville, Md, USA , pages 1808 - 1815, XP055782658, ISSN: 0032-0889, DOI: 10.1104/pp.102.018846
THANBICHLER MARTIN, NEUHIERL BERNHARD, BÖCK AUGUST: "S -Methylmethionine Metabolism in Escherichia coli", JOURNAL OF BACTERIOLOGY (PRINT), AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 181, no. 2, 15 January 1999 (1999-01-15), US , pages 662 - 665, XP055909981, ISSN: 0021-9193, DOI: 10.1128/JB.181.2.662-665.1999
THANBICHLER MARTIN, NEUHIERL BERNHARD, BÖCK AUGUST: "S -Methylmethionine Metabolism in Escherichia coli", JOURNAL OF BACTERIOLOGY (PRINT), AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 181, no. 2, 15 January 1999 (1999-01-15), US , pages 662 - 665, XP055909981, ISSN: 0021-9193, DOI: 10.1128/JB.181.2.662-665.1999
Attorney, Agent or Firm:
JUNG, Eun Youl et al. (KR)
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