Title:
REMEDIES FOR DRY EYE
Document Type and Number:
WIPO Patent Application WO/1998/051313
Kind Code:
A1
Abstract:
Novel effects and medicinal uses of 1$g(a),24-dihydroxylated vitamin D�3?, that is, (1) remedies for dry eye, (2) differentiation inhibitors for cornified corneal epithelial cells, and (3) transglutaminase I (TG-I) expression inhibitors, each containing 1$g(a),24-dihydroxylated vitamin D�3? as the active ingredient.
Inventors:
NAKATA KATSUHIKO (JP)
NAKAMURA MASATSUGU (JP)
HAZATO ATSUO (JP)
NAKAMURA MASATSUGU (JP)
HAZATO ATSUO (JP)
Application Number:
PCT/JP1998/002080
Publication Date:
November 19, 1998
Filing Date:
May 12, 1998
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
TEIJIN LTD (JP)
NAKATA KATSUHIKO (JP)
NAKAMURA MASATSUGU (JP)
HAZATO ATSUO (JP)
TEIJIN LTD (JP)
NAKATA KATSUHIKO (JP)
NAKAMURA MASATSUGU (JP)
HAZATO ATSUO (JP)
International Classes:
A61K31/59; A61P27/02; A61P43/00; (IPC1-7): A61K31/59
Domestic Patent References:
| WO1997018817A1 | 1997-05-29 | |||
| WO1996029079A1 | 1996-09-26 |
Other References:
SATO H., ET AL.: "TACALCITOL (1,24(OH)2D3, TV-O2) INHIBITS PHORBOL ESTER-INDUCED EPIDERMAL PROLIFERATION AND CUTANEOUS INFLAMMATION, AND INDUCES EPIDERMAL DIFFERENTIATION IN MICE.", ARCHIVES OF DERMATOLOGICAL RESEARCH., SPRINGER, INTERNATIONAL, BERLIN., DE, vol. 288., 1 January 1996 (1996-01-01), DE, pages 656 - 663., XP002914416, ISSN: 0340-3696, DOI: 10.1007/s004030050120
MATSUNAGA T, ET AL.: "EFFECTS OF 1,24(R)-(OH)2D3 ON EPIDERMAL CELL DIFFERENTIATION IN MICE", YAKURI TO CHIRYO - JAPANESE PHARMACOLOGY AND THERAPEUTICS., RAIFU SAIENSU SHUPPAN, TOKYO., JP, vol. 21, no. 12, 1 January 1993 (1993-01-01), JP, pages 4573 - 4579, XP002917214, ISSN: 0386-3603
See also references of EP 0998931A4
MATSUNAGA T, ET AL.: "EFFECTS OF 1,24(R)-(OH)2D3 ON EPIDERMAL CELL DIFFERENTIATION IN MICE", YAKURI TO CHIRYO - JAPANESE PHARMACOLOGY AND THERAPEUTICS., RAIFU SAIENSU SHUPPAN, TOKYO., JP, vol. 21, no. 12, 1 January 1993 (1993-01-01), JP, pages 4573 - 4579, XP002917214, ISSN: 0386-3603
See also references of EP 0998931A4
Attorney, Agent or Firm:
Kishimoto, Einosuke (13-18 Nishishinsaibashi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
Download PDF: