Title:
RESVERATROL-LECITHIN NANOPARTICLE, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/193389
Kind Code:
A1
Abstract:
Provided is a resveratrol-lecithin nanoparticle comprising resveratrol and lecithin encapsulating and/or conjugated to resveratrol. The resveratrol-lecithin nanoparticle features safety and sustained release, and can improve the in-vivo bioavailability of resveratrol, enhance the time of in-vivo exposure, promote the targeting performance to tumor tissues, and improve the killing effect on tumor cells, thus having more significant anti-tumor and antioxidant effects.
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Inventors:
YAO YANDAN (CN)
CAI PEIE (CN)
CAI PEIE (CN)
Application Number:
PCT/CN2022/114615
Publication Date:
October 12, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV (CN)
International Classes:
A61K9/51; A61K31/05; A61K31/685; A61K47/55; A61P35/00; A61P39/06
Foreign References:
| CN114681430A | 2022-07-01 | |||
| CN112773728A | 2021-05-11 | |||
| US20160213584A1 | 2016-07-28 | |||
| CN101095664A | 2008-01-02 |
Other References:
WANG ZHAOMING, HE ZHI-FEI, YU, LI, LI HONG-JUN: "Function effects and analysis methods of Lecithin of animal", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, GAI KAN BIANJIBU , BEIJING, CN, vol. 35, no. 19, 31 December 2014 (2014-12-31), CN , pages 362 - 367, XP093097156, ISSN: 1002-0306, DOI: 10.13386/j.issn1002-0306.2014.19.071
YANG JUAN, ZHONG YING; SHANG SHU-YU; JIA AN: "Preparation and in Vivo Pharmacokinetics of Solid Lipid Nanoparticles of Resveratrol Phospholipids Complex", CHINESE TRADITIONAL PATENT MEDICINE, GUOJIA YIYAO GUANLIJU, ZHONGCHENGYAO QINGBAO ZHONGXINZHAN, CN, vol. 43, no. 4, 30 April 2021 (2021-04-30), CN , pages 841 - 846, XP093097157, ISSN: 1001-1528, DOI: 10.3969/j.issn.1001-1528.2021.04.001
YANG JUAN, ZHONG YING; SHANG SHU-YU; JIA AN: "Preparation and in Vivo Pharmacokinetics of Solid Lipid Nanoparticles of Resveratrol Phospholipids Complex", CHINESE TRADITIONAL PATENT MEDICINE, GUOJIA YIYAO GUANLIJU, ZHONGCHENGYAO QINGBAO ZHONGXINZHAN, CN, vol. 43, no. 4, 30 April 2021 (2021-04-30), CN , pages 841 - 846, XP093097157, ISSN: 1001-1528, DOI: 10.3969/j.issn.1001-1528.2021.04.001
Attorney, Agent or Firm:
GUANGZHOU RUNHE INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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