Title:
AN RNA APTAMER THAT BINDS TO ASP7967 OR AN ANALOGUE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/075841
Kind Code:
A1
Abstract:
It is an object of the present invention to provide an RNA aptamer capable of binding to ASP7967 or an analogue thereof. The RNA aptamer of the present invention is an RNA aptamer that binds to ASP7967 or an analogue thereof, comprising a sequence: -X1-L1-X2-L2-X3-, wherein X1 has the sequence Y1GY2GY3Y4Y5; L1 is a first stem loop nucleotide sequence comprising a first stem region, a first loop region and a second stem region, wherein the first stem region and the second stem region are 2 or more base pair long and are substantially complementary to each other; X2 is A, G, C or U, L2 is a second stem loop nucleotide sequence comprising a third stem region, a second loop region and a fourth stem region, wherein the third stem region and the fourth stem region are 2 or more base pair long and are substantially complementary to each other; and wherein the first base in the third stem region is G and the last base in the fourth stem region is C; X3 has the sequence UY6; and Y1, Y2, Y3, Y4, Y5, and Y6 are, each independently, A, G, C or U; or a sequence: -S1-X2-L2-X3-L3-X1-S2-, wherein S1 and S2 are, each independently, A, G, C or U, and S1 and S2 are capable of forming a base pair or a wobble base pair with each other; L3 is a third stem loop nucleotide sequence comprising a fifth stem region, a third loop region and a sixth stem region, wherein the fifth stem region and the sixth stem region are 1 or more base pair long and are substantially complementary to each other; and X1, X2, X3, and L2 are as defined above; or a sequence: -S3-X3-L3-X1-L1-X2-S4-, wherein S3 is C and S4 is G; and X1, X2, X3, L1, and L3 are as defined above.
Inventors:
YOKOBAYASHI YOHEI (JP)
DHAMODHARAN VENUGOPAL (JP)
FUKUNAGA KEISUKE (JP)
MIYAHIRA NAO (JP)
FUJIYASU JIRO (JP)
ISHIKAWA SHIZUMA (JP)
OOSUMI YASUAKI (JP)
DHAMODHARAN VENUGOPAL (JP)
FUKUNAGA KEISUKE (JP)
MIYAHIRA NAO (JP)
FUJIYASU JIRO (JP)
ISHIKAWA SHIZUMA (JP)
OOSUMI YASUAKI (JP)
Application Number:
PCT/JP2023/036570
Publication Date:
April 11, 2024
Filing Date:
October 06, 2023
Export Citation:
Assignee:
OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP)
International Classes:
C12N15/115; C12N15/11
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES (JP)
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