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Title:
RNA INHIBITOR FOR INHIBITING APOC3 GENE EXPRESSION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/027809
Kind Code:
A1
Abstract:
The present invention pertains to the field of biopharmaceutics, and particularly relates to an RNA inhibitor for inhibiting APOC3 gene expression or a pharmaceutically acceptable salt thereof. The RNA inhibitor comprises a sense strand and an antisense strand. The sense strand and the antisense strand are each independently 15-30 nucleotides, preferably 19-23 nucleotides in length. At least 80% of the bases are complementary between the sense strand and the antisense strand. The RNA inhibitor further comprises the carrier structures 5'MVIP and 3'MVIP. The present application further relates to a pharmaceutical composition comprising the RNA inhibitor for inhibiting APOC3 gene expression and use thereof in the treatment and prevention of cardiovascular and cerebrovascular diseases.

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Inventors:
CUI KUNYUAN (CN)
LU XUEQIN (CN)
Application Number:
PCT/CN2023/111121
Publication Date:
February 08, 2024
Filing Date:
August 04, 2023
Export Citation:
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Assignee:
KYLONOVA XIAMEN BIOPHARMA CO LTD (CN)
International Classes:
C12N15/113; A61K31/713; A61P1/16; A61P3/06; A61P7/02; A61P9/00; A61P9/10; A61P29/00
Foreign References:
CN111107853A2020-05-05
CN113171371A2021-07-27
US20170260527A12017-09-14
CN108743943A2018-11-06
CN113293163A2021-08-24
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