Title:
SARS-COV-2 PROTEIN-DERIVED PEPTIDE AND VACCINE CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2022/149549
Kind Code:
A1
Abstract:
The present invention provides a SARS-CoV-2 protein-derived epitope peptide capable of inducing cytotoxic T cells. The present invention also provides: a polynucleotide coding for the peptide; an antigen-presenting cell presenting the peptide; a cytotoxic T cell (CTL) targeting the peptide; and a method for inducing the antigen-presenting cell or the CTL. The present invention further provides a composition or a pharmaceutical composition containing the foregoing as an active ingredient. Furthermore, the present invention provides a method for treating and/or preventing the coronavirus infectious disease, and/or a method for suppressing worsening of the disease, using the peptide, the polynucleotide, the antigen-presenting cell, the cytotoxic T cell, or the pharmaceutical composition according to the present invention. Also provided is a method for inducing an immune response to a coronavirus infection. Also provided is a method for checking the history of a coronavirus infection by detecting a TCR sequence in a target.
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Inventors:
KIYOTANI KAZUMA (JP)
NAKAMURA YUSUKE (JP)
HIKICHI TETSURO (JP)
NAKAMURA YUSUKE (JP)
HIKICHI TETSURO (JP)
Application Number:
PCT/JP2021/048846
Publication Date:
July 14, 2022
Filing Date:
December 28, 2021
Export Citation:
Assignee:
ONCOTHERAPY SCIENCE INC (JP)
CANCER PREC MEDICINE INC (JP)
KIYOTANI KAZUMA (JP)
NAKAMURA YUSUKE (JP)
CANCER PREC MEDICINE INC (JP)
KIYOTANI KAZUMA (JP)
NAKAMURA YUSUKE (JP)
International Classes:
C12N15/50; A61K9/107; A61K35/12; A61K35/15; A61K35/17; A61K39/00; A61K39/215; A61K39/39; A61K48/00; A61P31/14; A61P37/04; C07K7/06; C07K7/08; C07K16/10; C12N5/0783; C12N5/10; C12N15/12; C12N15/13; C12P21/08; C12Q1/02
Domestic Patent References:
| WO2015075939A1 | 2015-05-28 |
Foreign References:
| CN112034174A | 2020-12-04 |
Other References:
UL QAMAR MUHAMMAD TAHIR, REHMAN ABDUR, ASHFAQ USMAN ALI, AWAN MUHAMMAD QASIM, FATIMA ISRAR, SHAHID FARAH, CHEN LING-LING: "Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches", BIORXIV, 22 March 2020 (2020-03-22), pages 1 - 36, XP055890937, Retrieved from the Internet [retrieved on 20220214], DOI: 10.1101/2020.02.28.970343
BUSSMANN, B.M. REICHE, S. JACOB, L.H. BRAUN, J.M. JASSOY, C.: "Antigenic and cellular localisation analysis of the severe acute respiratory syndrome coronavirus nucleocapsid protein using monoclonal antibodies", VIRUS RESEARCH, AMSTERDAM, NL, vol. 122, no. 1-2, 1 December 2006 (2006-12-01), NL , pages 119 - 126, XP005720342, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2006.07.005
STEPHEN N. CROOKE, OVSYANNIKOVA INNA G., KENNEDY RICHARD B., POLAND GREGORY A.: "Immunoinformatic identification of B cell and T cell epitopes in the SARS-CoV-2 proteome", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 December 2020 (2020-12-01), XP055770118, DOI: 10.1038/s41598-020-70864-8
WU FAN; ZHAO SU; YU BIN; CHEN YAN-MEI; WANG WEN; SONG ZHI-GANG; HU YI; TAO ZHAO-WU; TIAN JUN-HUA; PEI YUAN-YUAN; YUAN MING-LI; ZHA: "A new coronavirus associated with human respiratory disease in China", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 579, no. 7798, 3 February 2020 (2020-02-03), London, pages 265 - 269, XP037060203, ISSN: 0028-0836, DOI: 10.1038/s41586-020-2008-3
AKHAND MST RUBAIAT NAZNEEN; AZIM KAZI FAIZUL; HOQUE SYEDA FARJANA; MOLI MAHMUDA AKTHER; JOY BIJIT DAS; AKTER HAFSA; AFIF IBRAHIM K: "Genome based evolutionary lineage of SARS-CoV-2 towards the development of novel chimeric vaccine", INFECTION , GENETICS AND EVOLUTION, ELSEVIER, AMSTERDAM, NL, vol. 85, 1 September 2020 (2020-09-01), NL , XP086352743, ISSN: 1567-1348, DOI: 10.1016/j.meegid.2020.104517
Y. TANAKA, H. NAKASONE, R. YAMAZAKI, K. SATO, M. SATO, K. TERASAKO, S.-I. KIMURA, S. OKUDA, S. KAKO, K. OSHIMA, A. TANIHARA, J. NI: "Single-Cell Analysis of T-Cell Receptor Repertoire of HTLV-1 Tax-Specific Cytotoxic T Cells in Allogeneic Transplant Recipients with Adult T-Cell Leukemia/Lymphoma", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 70, no. 15, 1 August 2010 (2010-08-01), pages 6181 - 6192, XP055075777, ISSN: 00085472, DOI: 10.1158/0008-5472.CAN-10-0678
MIYAZAKI ERIKO, KAWANA-TACHIKAWA AI, TOMIZAWA MARIKO, NUNOYA JUN-ICHI, ODAWARA TAKASHI, FUJII TAKESHI, SHI YI, GAO GEORGE FU, IWAM: "Highly restricted T-cell receptor repertoire in the CD8+ T-cell response against an HIV-1 epitope with a stereotypic amino acid substitution", AIDS, LONDON, GB, vol. 23, no. 6, 27 March 2009 (2009-03-27), GB , pages 651 - 660, XP055949891, ISSN: 0269-9370, DOI: 10.1097/QAD.0b013e32832605e6
ZHONG, W. DIXIT, S.B. MALLIS, R.J. ARTHANARI, H. LUGOVSKOY, A.A. BEVERIDGE, D.L. WAGNER, G. REINHERZ, E.L.: "CTL Recognition of a Protective Immunodominant Influenza A Virus Nucleoprotein Epitope Utilizes a Highly Restricted V@b but Diverse V@a Repertoire: Functional and Structural Implications", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 372, no. 2, 21 August 2007 (2007-08-21), United Kingdom , pages 535 - 548, XP022208314, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2007.06.057
BUSSMANN, B.M. REICHE, S. JACOB, L.H. BRAUN, J.M. JASSOY, C.: "Antigenic and cellular localisation analysis of the severe acute respiratory syndrome coronavirus nucleocapsid protein using monoclonal antibodies", VIRUS RESEARCH, AMSTERDAM, NL, vol. 122, no. 1-2, 1 December 2006 (2006-12-01), NL , pages 119 - 126, XP005720342, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2006.07.005
STEPHEN N. CROOKE, OVSYANNIKOVA INNA G., KENNEDY RICHARD B., POLAND GREGORY A.: "Immunoinformatic identification of B cell and T cell epitopes in the SARS-CoV-2 proteome", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 December 2020 (2020-12-01), XP055770118, DOI: 10.1038/s41598-020-70864-8
WU FAN; ZHAO SU; YU BIN; CHEN YAN-MEI; WANG WEN; SONG ZHI-GANG; HU YI; TAO ZHAO-WU; TIAN JUN-HUA; PEI YUAN-YUAN; YUAN MING-LI; ZHA: "A new coronavirus associated with human respiratory disease in China", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 579, no. 7798, 3 February 2020 (2020-02-03), London, pages 265 - 269, XP037060203, ISSN: 0028-0836, DOI: 10.1038/s41586-020-2008-3
AKHAND MST RUBAIAT NAZNEEN; AZIM KAZI FAIZUL; HOQUE SYEDA FARJANA; MOLI MAHMUDA AKTHER; JOY BIJIT DAS; AKTER HAFSA; AFIF IBRAHIM K: "Genome based evolutionary lineage of SARS-CoV-2 towards the development of novel chimeric vaccine", INFECTION , GENETICS AND EVOLUTION, ELSEVIER, AMSTERDAM, NL, vol. 85, 1 September 2020 (2020-09-01), NL , XP086352743, ISSN: 1567-1348, DOI: 10.1016/j.meegid.2020.104517
Y. TANAKA, H. NAKASONE, R. YAMAZAKI, K. SATO, M. SATO, K. TERASAKO, S.-I. KIMURA, S. OKUDA, S. KAKO, K. OSHIMA, A. TANIHARA, J. NI: "Single-Cell Analysis of T-Cell Receptor Repertoire of HTLV-1 Tax-Specific Cytotoxic T Cells in Allogeneic Transplant Recipients with Adult T-Cell Leukemia/Lymphoma", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 70, no. 15, 1 August 2010 (2010-08-01), pages 6181 - 6192, XP055075777, ISSN: 00085472, DOI: 10.1158/0008-5472.CAN-10-0678
MIYAZAKI ERIKO, KAWANA-TACHIKAWA AI, TOMIZAWA MARIKO, NUNOYA JUN-ICHI, ODAWARA TAKASHI, FUJII TAKESHI, SHI YI, GAO GEORGE FU, IWAM: "Highly restricted T-cell receptor repertoire in the CD8+ T-cell response against an HIV-1 epitope with a stereotypic amino acid substitution", AIDS, LONDON, GB, vol. 23, no. 6, 27 March 2009 (2009-03-27), GB , pages 651 - 660, XP055949891, ISSN: 0269-9370, DOI: 10.1097/QAD.0b013e32832605e6
ZHONG, W. DIXIT, S.B. MALLIS, R.J. ARTHANARI, H. LUGOVSKOY, A.A. BEVERIDGE, D.L. WAGNER, G. REINHERZ, E.L.: "CTL Recognition of a Protective Immunodominant Influenza A Virus Nucleoprotein Epitope Utilizes a Highly Restricted V@b but Diverse V@a Repertoire: Functional and Structural Implications", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 372, no. 2, 21 August 2007 (2007-08-21), United Kingdom , pages 535 - 548, XP022208314, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2007.06.057
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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