Title:
SECRETED POLYPEPTIDE SPECIES ASSOCIATED WITH CARDIOVASCULAR DISORDERS
Document Type and Number:
WIPO Patent Application WO2004106941
Kind Code:
A3
Abstract:
The invention discloses human secreted polypeptides that circulate at an increased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and for drug development.
Inventors:
BOUGUELERET LYDIE (CH)
Application Number:
PCT/EP2004/005786
Publication Date:
May 26, 2005
Filing Date:
May 28, 2004
Export Citation:
Assignee:
GENOVA LTD
NOVARTIS PHARMA GMBH (AT)
BOUGUELERET LYDIE (CH)
NOVARTIS PHARMA GMBH (AT)
BOUGUELERET LYDIE (CH)
International Classes:
G01N33/50; G01N33/68; G01N33/92; (IPC1-7): G01N33/92; G01N33/50
Domestic Patent References:
| WO2001030354A1 | 2001-05-03 |
Foreign References:
| US5641497A | 1997-06-24 |
Other References:
HIGAZI ABD AL-ROOF ET AL: "Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells", BLOOD, vol. 89, no. 12, 1997, pages 4290 - 4298, XP002299296, ISSN: 0006-4971
TANG YI-QUAN ET AL: "Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes", INFECTION AND IMMUNITY, vol. 67, no. 11, November 1999 (1999-11-01), pages 6139 - 6144, XP002299297, ISSN: 0019-9567
TANG YI-QUAN ET AL: "Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes", INFECTION AND IMMUNITY, vol. 67, no. 11, November 1999 (1999-11-01), pages 6139 - 6144, XP002299297, ISSN: 0019-9567
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