Title:
SELECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/168178
Kind Code:
A1
Abstract:
Disclosed is a method for selecting a subject to whom resveratrol originating in melinjo is to be administered for promoting multimerization of adiponectin, said method comprising a step wherein a subject person is selected as the subject to whom resveratrol melinjo is to be administered in the case where s/he shows: (1) genotype G/T or genotype T/T in DsbA-L rs1917760 (-1308G/T); and/or (2) a DsbA-LmRNA expression amount in peripheral blood monocytes at a preset level or lower.
Inventors:
ONIKI KENTARO (JP)
NAKASHIMA AZUSA (JP)
SARUWATARI JUNJI (JP)
NAKASHIMA AZUSA (JP)
SARUWATARI JUNJI (JP)
Application Number:
PCT/JP2019/008216
Publication Date:
September 06, 2019
Filing Date:
March 01, 2019
Export Citation:
Assignee:
YAMADA BEE CO INC (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
C12Q1/686; C12Q1/06; C12Q1/6881; C12N15/12
Foreign References:
| JP2008255040A | 2008-10-23 | |||
| JP2011032173A | 2011-02-17 |
Other References:
WANG, A ET AL.: "Up-regulation of Adiponectin by Resveratrol THE ESSENTIAL ROLES OF THE Akt/FOXOl AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 1, 2011, pages 60 - 66, XP002645892, doi:10.1074/jbc.M110.188144
GAO, F ET AL.: "Polymorphism of DsbA-L Gene Associates with Insulin Secretion and Body Fat Distribution in Chinese Population", ENDOCRINE JOURNAL, vol. 56, no. 3, 2009, pages 487 - 494, XP055634492
LIU,M ET AL.: "Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance", DIABETES, vol. 61, no. 11, November 2012 (2012-11-01), pages 2776 - 2786, XP055634500
ONIKI KENTARO ET AL.: "A multifaceted approach regarding the Association of the DsbA-L gene with the risk of the obesity related diseases based on clinical pharmacogenetics", ABSTRACTS OF THE 138TH ANNUAL CONFERENCE OF THE PHARMACEUTICAL SOCIETY OF JAPAN, no. S70-5, March 2018 (2018-03-01), pages 322
GAO, F ET AL.: "Polymorphism of DsbA-L Gene Associates with Insulin Secretion and Body Fat Distribution in Chinese Population", ENDOCRINE JOURNAL, vol. 56, no. 3, 2009, pages 487 - 494, XP055634492
LIU,M ET AL.: "Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance", DIABETES, vol. 61, no. 11, November 2012 (2012-11-01), pages 2776 - 2786, XP055634500
ONIKI KENTARO ET AL.: "A multifaceted approach regarding the Association of the DsbA-L gene with the risk of the obesity related diseases based on clinical pharmacogenetics", ABSTRACTS OF THE 138TH ANNUAL CONFERENCE OF THE PHARMACEUTICAL SOCIETY OF JAPAN, no. S70-5, March 2018 (2018-03-01), pages 322
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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