Title:
SELECTIVE R-CADHERIN ANTAGONISTS AND METHODS
Document Type and Number:
WIPO Patent Application WO2004099232
Kind Code:
A3
Abstract:
An isolated peptide useful as a selective antagonist of mammalian R-cadherin comprises 3 to 30 amino acid residues, three contiguous residues of the peptide having the amino acid sequence I1e-Xaa-Ser; wherein Xaa is an amino acid residue selected from the group consisting of Asp, Asn, Glu, and Gln. Preferably Xaa is Asp or Asn. In one preferred embodiment the peptide is a cyclic peptide having 3 to 10 amino acid residues arranged in a ring. The selective R-cadherin antagonist peptides of the invention are useful for inhibiting the targeting of stem cells, such as endothelial precursor cells, to developing vasculature, for inhibiting R-cadherin mediated cellular adhesion, and for inhibiting retinal angiogenesis.
Inventors:
FRIEDLANDER MARTIN (US)
DORRELL MICHAEL I (US)
DORRELL MICHAEL I (US)
Application Number:
PCT/US2004/013212
Publication Date:
May 19, 2005
Filing Date:
April 30, 2004
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
FRIEDLANDER MARTIN (US)
DORRELL MICHAEL I (US)
FRIEDLANDER MARTIN (US)
DORRELL MICHAEL I (US)
International Classes:
A61K38/00; A61K38/06; A61K38/08; A61K38/10; A61K38/12; C07K14/705; C07K; (IPC1-7): A61K38/00
Domestic Patent References:
| WO2000002917A2 | 2000-01-20 |
Foreign References:
| US6472368B1 | 2002-10-29 |
Other References:
"CAS Protein Sequences on STN Quick Reference Guide, January 2001, Pg 12", QUICK REFERENCE GUIDE CAS, XX, XX, 1 January 2001 (2001-01-01), XX, pages 12, XP003018441
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