Title:
SENSITISER FOR CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2021/256427
Kind Code:
A1
Abstract:
It is still unclear which usage amounts of cancer-treatment sensitisers and which methods of use thereof are effective for tumours and what timetable for cancer treatments such as radiotherapy or anti-cancer chemotherapy is effective after administering a sensitiser. The inventors of the present invention solved this problem by demonstrating that, by injecting a specific amount of a cancer-treatment sensitiser, which is produced by combining H2O2 in a specified concentration range with hyaluronic acid, into a tumour-effected area in a specific procedure, it is possible to increase the effectiveness of cancer treatments such as radiotherapy or anti-cancer chemotherapy.
Inventors:
NAVITA SOMAIAH (GB)
OGAWA YASUHIRO (JP)
OGAWA YASUHIRO (JP)
Application Number:
PCT/JP2021/022520
Publication Date:
December 23, 2021
Filing Date:
June 14, 2021
Export Citation:
Assignee:
KORTUC INC (JP)
International Classes:
A61K33/40; A61K31/728
Domestic Patent References:
| WO2008041514A1 | 2008-04-10 | |||
| WO2014126222A1 | 2014-08-21 | |||
| WO1999010385A1 | 1999-03-04 | |||
| WO2001057093A1 | 2001-08-09 |
Foreign References:
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| JP2016014066A | 2016-01-28 | |||
| JP2006345701A | 2006-12-28 | |||
| JPS63123392A | 1988-05-27 | |||
| JPH02234689A | 1990-09-17 | |||
| EP0341745B1 | 1994-12-14 | |||
| JP2003252905A | 2003-09-10 | |||
| JPH01266102A | 1989-10-24 |
Other References:
OGAWA, YASUHIRO : "Remarkable therapeutic effects of newly developed radiosensitizer containing hydrogen peroxide and sodium hyaluronate", ANNUAL REPORT OF CENTER FOR REGIONAL & INTERNATIONAL COLLABORATION, vol. 2008, 2008, pages 54 - 57, XP009542726
GINSBURG OBRAY FCOLEMAN MP ET AL.: "The global burden of women's cancers: A grand challenge in global health", LANCET, vol. 389, 2017, pages 847 - 860
OGAWA YTAKAHASHI TKOBAYASHI T ET AL.: "Mechanism of hydrogen peroxide-induced apoptosis of the human osteosarcoma cell line hs-os-1", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 12, 2003, pages 459 - 63, XP003022239
KARIYA SSAWADA KKOBAYASHI T ET AL.: "Combination treatment of hydrogen peroxide and x-rays induces apoptosis in human prostate cancer pc-3 cells", INT J RADIAT ONCOL BIOL PHYS, vol. 75, 2009, pages 449 - 54, XP026714743, DOI: 10.1016/j.ijrobp.2009.04.092
ERIKSSON DSTIGBRAND T: "Radiation-induced cell death mechanisms", TUMOUR BIOL, vol. 31, 2010, pages 363 - 72
KATSUBE TMORI MTSUJI H ET AL.: "Most hydrogen peroxide-induced histone h2ax phosphorylation is mediated by atr and is not dependent on DNA double-strand breaks", J BIOCHEM, vol. 156, 2014, pages 85 - 95
OGAWA YTAKAHASHI TKOBAYASHI T ET AL.: "Apoptotic-resistance of the human osteosarcoma cell line hs-os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide: A potent role of hydrogen peroxide as a new radiosensitizer", INT J MOL MED, vol. 12, 2003, pages 845 - 50, XP003022238
AKIMA ROGAWA YMORITA-TOKUHIRO S ET AL.: "New enzyme-targeting radiosensitizer (kortuc) containing hydrogen peroxide & sodium hyaluronate for intratumoral injection using mice transplanted with sccvii tumor", INT J CANCER CLIN RES, vol. 3, 2016, pages 1 - 6
C. YOMOTA, BULL. NATL. INST. HEALTH SCI., vol. 121, 2003, pages 030 - 033
CARBOHYDR. RES, vol. 245, 1993, pages 113 - 128
MACROMOLECULES, vol. 29, 1996, pages 2894 - 2902
GINSBURG OBRAY FCOLEMAN MP ET AL.: "The global burden of women's cancers: A grand challenge in global health", LANCET, vol. 389, 2017, pages 847 - 860
OGAWA YTAKAHASHI TKOBAYASHI T ET AL.: "Mechanism of hydrogen peroxide-induced apoptosis of the human osteosarcoma cell line hs-os-1", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 12, 2003, pages 459 - 63, XP003022239
KARIYA SSAWADA KKOBAYASHI T ET AL.: "Combination treatment of hydrogen peroxide and x-rays induces apoptosis in human prostate cancer pc-3 cells", INT J RADIAT ONCOL BIOL PHYS, vol. 75, 2009, pages 449 - 54, XP026714743, DOI: 10.1016/j.ijrobp.2009.04.092
ERIKSSON DSTIGBRAND T: "Radiation-induced cell death mechanisms", TUMOUR BIOL, vol. 31, 2010, pages 363 - 72
KATSUBE TMORI MTSUJI H ET AL.: "Most hydrogen peroxide-induced histone h2ax phosphorylation is mediated by atr and is not dependent on DNA double-strand breaks", J BIOCHEM, vol. 156, 2014, pages 85 - 95
OGAWA YTAKAHASHI TKOBAYASHI T ET AL.: "Apoptotic-resistance of the human osteosarcoma cell line hs-os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide: A potent role of hydrogen peroxide as a new radiosensitizer", INT J MOL MED, vol. 12, 2003, pages 845 - 50, XP003022238
AKIMA ROGAWA YMORITA-TOKUHIRO S ET AL.: "New enzyme-targeting radiosensitizer (kortuc) containing hydrogen peroxide & sodium hyaluronate for intratumoral injection using mice transplanted with sccvii tumor", INT J CANCER CLIN RES, vol. 3, 2016, pages 1 - 6
C. YOMOTA, BULL. NATL. INST. HEALTH SCI., vol. 121, 2003, pages 030 - 033
CARBOHYDR. RES, vol. 245, 1993, pages 113 - 128
MACROMOLECULES, vol. 29, 1996, pages 2894 - 2902
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
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