Title:
SENSITIZER AND ERYTHROCYTIC DIAGNOSTIC AGENT FOR DIAGNOSING MALIGNANT NEOPLASMS, METHODS FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2012/030256
Kind Code:
A3
Abstract:
The invention relates to medicine. The sensitizer for an erythrocytic diagnostic agent for diagnosing the presence of malignant neoplasms comprises a mixture of fractions of low-molecular protein compounds with a molecular mass of 3000-15000 Da, which is extracted from the blood serum of a pregnant mare in the early stage of pregnancy and exhibits a stimulating effect on the proliferation of malignant cells. The method for producing the sensitizer includes obtaining the serum, fractionating same by liquid chromatography and extracting a mixture of fractions of protein compounds with a molecular mass of 3000-15000 Da. The erythrocytic diagnostic agent contains formalized sheep erythrocytes sensitized with the aforementioned sensitizer. The method for producing the diagnostic agent includes sensibilizing a suspension of formalized erythrocytes with the sensitizer. The method for diagnosing the presence of malignant neoplasms is carried out using the aforementioned erythrocytic diagnostic agent.
Inventors:
BALYURA ALEXANDR VLADIMIROVICH (RU)
MOLODYK ALVINA ALFREDOVNA (RU)
SAVLUCHYNSKAYA LYUDMILA ALEXANDROVNA (RU)
TARASOV SERGEY GENNADEVICH (RU)
MOLODYK ALVINA ALFREDOVNA (RU)
SAVLUCHYNSKAYA LYUDMILA ALEXANDROVNA (RU)
TARASOV SERGEY GENNADEVICH (RU)
Application Number:
PCT/RU2011/000655
Publication Date:
May 18, 2012
Filing Date:
August 29, 2011
Export Citation:
Assignee:
BALYURA ALEXANDR VLADIMIROVICH (RU)
MOLODYK ALVINA ALFREDOVNA (RU)
SAVLUCHYNSKAYA LYUDMILA ALEXANDROVNA (RU)
TARASOV SERGEY GENNADEVICH (RU)
MOLODYK ALVINA ALFREDOVNA (RU)
SAVLUCHYNSKAYA LYUDMILA ALEXANDROVNA (RU)
TARASOV SERGEY GENNADEVICH (RU)
International Classes:
G01N33/574; A61K38/02; C07K1/16; G01N33/556; G01N33/68
Foreign References:
| EA009007B1 | 2007-10-26 | |||
| SU1140788A1 | 1985-02-23 | |||
| JPH07196691A | 1995-08-01 | |||
| US6114136A | 2000-09-05 |
Other References:
KARELIN A.A. ET AL.: "Peptidomika-novoe napravlenie postgenomnykh tekhnologii.", VESTNIK ROSSIISKOY AKADEMII NAUK, vol. 75, no. 2, 2005, pages 139 - 149, XP008167967
See also references of EP 2613152A4
See also references of EP 2613152A4
Attorney, Agent or Firm:
MAYOROV, Oleg Nikolaevich (Strastonoy blvd. 4/3/3-office 9, Moscow 9, RU)
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