Title:
SEQUENCES FOR TARGETING METASTATIC CELLS
Document Type and Number:
WIPO Patent Application WO1999022773
Kind Code:
B1
Abstract:
The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.
Inventors:
THOMPSON TIMOTHY C
Application Number:
PCT/US1998/023542
Publication Date:
November 11, 1999
Filing Date:
November 05, 1998
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
International Classes:
C07K14/705; C12N15/113; A61K38/00; A61K48/00; (IPC1-7): C12N15/12; C12N15/11; C07K14/705; C12N15/85; A61K31/70; C07K16/28; G01N33/68
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