Title:
SILK FIBROIN/MANGANESE DIOXIDE COMPOSITE MICROSPHERE DRUG CARRIER HAVING CORE-SHELL STRUCTURE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/259489
Kind Code:
A1
Abstract:
A preparation method for a silk fibroin/manganese dioxide composite microsphere drug carrier having a core-shell structure, comprising: (1) adding a water-soluble organic solvent to an aqueous solution of silk fibroin, performing freezing and natural thawing, and removing the solvent to obtain silk fibroin nanospheres; and (2) mixing the obtained silk fibroin nanospheres with potassium permanganate and polyallylamine hydrochloride uniformly, performing incubation, and removing the solvent, so as to obtain a silk fibroin/manganese dioxide composite microsphere drug carrier having a core-shell structure in which the inner layer is silk fibroin and the outer layer is manganese dioxide. The process is simple and easy to operate. The obtained silk fibroin/manganese dioxide complex microsphere has a rough surface, combines excellent properties of silk fibroin and manganese dioxide, has a high drug loading rate, and can be released in a controlled manner in response to the tumor microenvironment, degrade hydrogen peroxide in the tumor environment to generate oxygen, and improve the efficiency of chemical and photodynamic therapy for tumor, having a wide application prospect in the fields of tumor therapy and medicine.
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Inventors:
YANG MINGYING (CN)
WANG JIE (CN)
CHEN YUYIN (CN)
CHEN YUPING (CN)
FAN XIN (CN)
WANG JIE (CN)
CHEN YUYIN (CN)
CHEN YUPING (CN)
FAN XIN (CN)
Application Number:
PCT/CN2020/097678
Publication Date:
December 30, 2020
Filing Date:
June 23, 2020
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61K9/50; A61K31/337; A61K31/704; A61K41/00; A61K47/02; A61K47/42; A61K47/52; A61K47/64; A61P35/00
Domestic Patent References:
| WO2016000032A1 | 2016-01-07 |
Foreign References:
| CN107184564A | 2017-09-22 | |||
| CN107670040A | 2018-02-09 | |||
| CN110251480A | 2019-09-20 | |||
| CN108529681A | 2018-09-14 |
Other References:
"Biomineralization-inspired Crystallization of Manganese Oxide on Silk Fibroin Nanoparticles for in vivo MR/fluorescence Imaging-assisted Tri-modal Therapy of Cancer", THERANOSTICS, vol. 9, no. 21, 14 August 2019 (2019-08-14), XP055770108, DOI: 910225426PX
Attorney, Agent or Firm:
HANGZHOU ZHIXIAN PATENT AGENCY (CN)
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