Title:
SINGLE-CELL ANALYSIS CHIP FOR ANTICANCER AGENT COMBINATION
Document Type and Number:
WIPO Patent Application WO/2019/013531
Kind Code:
A1
Abstract:
The analysis chip for determining an anticancer agent or an anticancer agent combination efficient with respect to a cancer cell, according to the present invention, comprises: a one-unit chamber for analyzing a single cancer cell; and a plurality of valves for controlling a fluid injected into the chamber, wherein the chamber comprises: a channel through which the fluid comprising an anticancer agent and a lysis buffer flows; a cell alignment unit for focusing on the cancer cell flowing through the channel; a cell capture unit for capturing the cancer cell focused on by the cell alignment unit; and an antibody array for capturing proteins secreted from the captured cancer cell, and intracellular proteins via lysis.
Inventors:
YANG SUNG (KR)
CHOI JONG CHAN (KR)
CHOI JONG CHAN (KR)
Application Number:
PCT/KR2018/007819
Publication Date:
January 17, 2019
Filing Date:
July 10, 2018
Export Citation:
Assignee:
GWANGJU INST SCIENCE & TECH (KR)
International Classes:
G01N33/50; B01L3/00; G01N33/68; G01N35/08
Foreign References:
| KR20100083987A | 2010-07-23 | |||
| KR20160052282A | 2016-05-12 | |||
| KR100968640B1 | 2010-07-06 | |||
| KR20100063011A | 2010-06-10 | |||
| KR20100060471A | 2010-06-07 |
Other References:
"Identifying novel drug combinations to overcome treatment resistance", 21 December 2016 (2016-12-21), XP055679732, Retrieved from the Internet
AL-LAZIKANI, B.: "Combinatorial drug therapy for cancer in the post-genomic era", NATURE BIOTECHNOLOGY, July 2012 (2012-07-01), pages 679 - 692, XP055370881
AL-LAZIKANI, B.: "Combinatorial drug therapy for cancer in the post-genomic era", NATURE BIOTECHNOLOGY, July 2012 (2012-07-01), pages 679 - 692, XP055370881
Attorney, Agent or Firm:
KIM, Ki Moon (KR)
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