SMALL INTERFERENCE RNA GENE THERAPY

Title:

SMALL INTERFERENCE RNA GENE THERAPY

Document Type and Number:

WIPO Patent Application WO2004065549

Kind Code:

A3

Abstract:

Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.

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Inventors:

CHANG LUNG-JI (US)
HE JIN (US)

Application Number:

PCT/US2004/001320

Publication Date:

March 24, 2005

Filing Date:

January 15, 2004

Export Citation:

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Assignee:

UNIV FLORIDA (US)
CHANG LUNG-JI (US)
HE JIN (US)

International Classes:

C12N15/11; C12N15/113; A61K48/00; (IPC1-7): A61K48/00; C07H21/04; C12N15/63

Foreign References:

US20020037281A1

2002-03-28

Other References:

ABBAS-TERKI T. ET AL.: "Lentiviral-mediated RNA interference", HUM. GENE THER., vol. 13, no. 18, 10 December 2002 (2002-12-10), pages 2197 - 2201, XP002978528
XIAO-FENG QIN ET AL.: "Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5", PNAS, vol. 100, no. 1, 7 January 2003 (2003-01-07), pages 183 - 188, XP002975768
See also references of EP 1590002A4

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