Title:
SMALL MOLECULE INHIBITOR FOR TARGETED INHIBITION OF PITPNM3 AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/160365
Kind Code:
A1
Abstract:
11 small molecule inhibitors having the biological effects of targeted inhibition of the PITPNM3-mediated cell adhesion and the biological effects of targeted inhibition of the CCL18-PITPNM3-mediated cell migration and adhesion, can inhibit various types of tumor metastases mediated by PITPNM3 activation such as breast cancer, hepatocellular carcinoma, pancreatic ductal cancer, and lung cancer, and have wide application range and strong targeting.
Inventors:
SONG ERWEI (CN)
GONG CHANG (CN)
JIANG WENGUO (CN)
LIU ZIHAO (CN)
GONG CHANG (CN)
JIANG WENGUO (CN)
LIU ZIHAO (CN)
Application Number:
PCT/CN2021/075050
Publication Date:
August 04, 2022
Filing Date:
February 03, 2021
Export Citation:
Assignee:
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV (CN)
International Classes:
A61K31/497; A61K31/192; A61K31/352; A61K31/4196; A61K31/422; A61K31/423; A61K31/495; A61P35/00
Domestic Patent References:
| WO2008017840A1 | 2008-02-14 |
Foreign References:
| CN102302488A | 2012-01-04 | |||
| CN102160895A | 2011-08-24 |
Other References:
DATABASE Registry ANONYMOUS : "- 2H-Indol-2-one, 1-[[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]methyl]- 1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 1-[[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]methyl]-1,3-dihydro-3- hydroxy-3-[2-(4-methoxypheny", XP055955397, retrieved from STN
DATABASE REGISTRY ANONYMOUS : " - Benzoic acid, 4-[[[9-(4-chlorophenyl)-1,5,6,7,8,9-hexahydro-8- oxo[1,2,4]triazolo[5,1-b]quinazolin-2-yl]thio]methyl]- (CA INDEX NAME) OTHER NAMES: CN - 4-[[9-(4-Chlorophenyl)-8-oxo-5,6,7,9-tetrahydro-4H-[1,2,4]triazolo[5,1- b]quinazolin-2-yl]sulfanylmethyl]benzoic acid MF", XP055955476, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "CN - Butanoic acid, 4-[(4-amino-6-ethyl-5,8-dihydro-6-methyl-6H- pyrano[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)thio]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-[(4-Amino-6-ethyl-5,8-dihydro-6-methyl-6H-pyrano[4',3':4,5]thieno[2,3- d]pyrimidin-2-yl)thio]butanoic acid MF -", XP055955479, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Acetic acid, 2-[[4-cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)- 4H-1,2,4-triazol-3-yl]thio]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 2-[[4-Cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4H-1,2,4- triazol-3-yl]thio]acetic acid MF - C16 H17 N3 O4 S SR ", XP055955481, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Acetic acid, 2-[[4-cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)- 4H-1,2,4-triazol-3-yl]thio]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 2-[[4-Cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4H-1,2,4- triazol-3-yl]thio]acetic acid MF - C16 H17 N3 O4 S SR ", XP055955483, retrieved from STN
DATABASE REGISTRY ANONYMOUS : " 5-Pyrimidinecarboxylic acid, 2-[[3-(1-methylethoxy)propyl]amino]-4-(1- methylethyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 2-[[3-(1-Methylethoxy)propyl]amino]-4-(1-methylethyl)-5- pyrimidinecarboxylic acid MF - C14 H23 N3 O3 SR - Chemical Library Supplier", XP055955485, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- D-Methionine, N-[3-(3,5-dimethyl-7-oxo-7H-furo[3,2-g][1]benzopyran-6-yl)-1- oxopropyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - N-[3-(3,5-Dimethyl-7-oxo-7H-furo[3,2-g][1]benzopyran-6-yl)-1-oxopropyl]-D- methionine FS - STEREOSEARCH MF - C21 H23 N O6 S SR - Chemic", XP055955486, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Propanoic acid, 3-[(2,3-dihydro-2-oxo-6-benzoxazolyl)sulfonyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 3-[(2,3-Dihydro-2-oxo-6-benzoxazolyl)sulfonyl]propanoic acid MF - C10 H9 N O6 S SR - Chemical Library Supplier: Interchim LC - STN Files: CA, CAPLUS, CHEMC", XP055955487, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 1H-Pyrazole-5-carboxamide, N-[2-[4-hydroxy-4,5-dimethyl-5-(4-methyl-3- penten-1-yl)-2-oxo-3-oxazolidinyl]ethyl]-1-methyl- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 1H-Pyrazole-5-carboxamide, N-[2-[4-hydroxy-4,5-dimethyl-5-(4-methyl-3- pentenyl)-2-oxo-3-oxazolidinyl]ethyl]-1", XP055955488, retrieved from STN
HONG RI, SHEN MIN-HE, XIE XIAO-HONG, RUAN SHAN-MING: "Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid", ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, TH, vol. 13, no. 5, 30 May 2012 (2012-05-30), TH , pages 1877 - 1880, XP055955490, ISSN: 1513-7368, DOI: 10.7314/APJCP.2012.13.5.1877
LIU, YUJIE ET AL.: "Discovery of CCL18 antagonist blocking breast cancer metastasis", CLINICAL & EXPERIMENTAL METASTASIS, vol. 36, no. 3, 6 May 2019 (2019-05-06), XP036787051, ISSN: 0262-0898, DOI: 10.1007/s10585-019-09965-2
DATABASE REGISTRY ANONYMOUS : " - Benzoic acid, 4-[[[9-(4-chlorophenyl)-1,5,6,7,8,9-hexahydro-8- oxo[1,2,4]triazolo[5,1-b]quinazolin-2-yl]thio]methyl]- (CA INDEX NAME) OTHER NAMES: CN - 4-[[9-(4-Chlorophenyl)-8-oxo-5,6,7,9-tetrahydro-4H-[1,2,4]triazolo[5,1- b]quinazolin-2-yl]sulfanylmethyl]benzoic acid MF", XP055955476, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "CN - Butanoic acid, 4-[(4-amino-6-ethyl-5,8-dihydro-6-methyl-6H- pyrano[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)thio]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-[(4-Amino-6-ethyl-5,8-dihydro-6-methyl-6H-pyrano[4',3':4,5]thieno[2,3- d]pyrimidin-2-yl)thio]butanoic acid MF -", XP055955479, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Acetic acid, 2-[[4-cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)- 4H-1,2,4-triazol-3-yl]thio]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 2-[[4-Cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4H-1,2,4- triazol-3-yl]thio]acetic acid MF - C16 H17 N3 O4 S SR ", XP055955481, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Acetic acid, 2-[[4-cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)- 4H-1,2,4-triazol-3-yl]thio]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 2-[[4-Cyclopropyl-5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4H-1,2,4- triazol-3-yl]thio]acetic acid MF - C16 H17 N3 O4 S SR ", XP055955483, retrieved from STN
DATABASE REGISTRY ANONYMOUS : " 5-Pyrimidinecarboxylic acid, 2-[[3-(1-methylethoxy)propyl]amino]-4-(1- methylethyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 2-[[3-(1-Methylethoxy)propyl]amino]-4-(1-methylethyl)-5- pyrimidinecarboxylic acid MF - C14 H23 N3 O3 SR - Chemical Library Supplier", XP055955485, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- D-Methionine, N-[3-(3,5-dimethyl-7-oxo-7H-furo[3,2-g][1]benzopyran-6-yl)-1- oxopropyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - N-[3-(3,5-Dimethyl-7-oxo-7H-furo[3,2-g][1]benzopyran-6-yl)-1-oxopropyl]-D- methionine FS - STEREOSEARCH MF - C21 H23 N O6 S SR - Chemic", XP055955486, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Propanoic acid, 3-[(2,3-dihydro-2-oxo-6-benzoxazolyl)sulfonyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 3-[(2,3-Dihydro-2-oxo-6-benzoxazolyl)sulfonyl]propanoic acid MF - C10 H9 N O6 S SR - Chemical Library Supplier: Interchim LC - STN Files: CA, CAPLUS, CHEMC", XP055955487, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 1H-Pyrazole-5-carboxamide, N-[2-[4-hydroxy-4,5-dimethyl-5-(4-methyl-3- penten-1-yl)-2-oxo-3-oxazolidinyl]ethyl]-1-methyl- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 1H-Pyrazole-5-carboxamide, N-[2-[4-hydroxy-4,5-dimethyl-5-(4-methyl-3- pentenyl)-2-oxo-3-oxazolidinyl]ethyl]-1", XP055955488, retrieved from STN
HONG RI, SHEN MIN-HE, XIE XIAO-HONG, RUAN SHAN-MING: "Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid", ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, TH, vol. 13, no. 5, 30 May 2012 (2012-05-30), TH , pages 1877 - 1880, XP055955490, ISSN: 1513-7368, DOI: 10.7314/APJCP.2012.13.5.1877
LIU, YUJIE ET AL.: "Discovery of CCL18 antagonist blocking breast cancer metastasis", CLINICAL & EXPERIMENTAL METASTASIS, vol. 36, no. 3, 6 May 2019 (2019-05-06), XP036787051, ISSN: 0262-0898, DOI: 10.1007/s10585-019-09965-2
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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