Title:
SMALL MOLECULE STING AGONIST, PREPARATION METHOD THEREFOR, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2023/103850
Kind Code:
A1
Abstract:
Provided are a small molecule STING agonist, a preparation method therefor, and an application. Specifically, the present invention provides the compound represented by structural formula I, the compound having STING agonist activity. The compound can significantly up-regulate IFN-β, CXCL10 and IL-6 mRNA expression levels, both in THP-1 cells and RAW264.7 cells, thereby achieving the purpose of treating malignant tumors and infectious diseases.
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Inventors:
ZHENG MINGYUE (CN)
HOU HUI (CN)
JIANG HUALIANG (CN)
ZHANG SULIN (CN)
YANG RUIRUI (CN)
SHAN BIN (CN)
LI RUI (CN)
ZHANG KEKE (CN)
SHI JIANMEI (CN)
LI XUTONG (CN)
HOU HUI (CN)
JIANG HUALIANG (CN)
ZHANG SULIN (CN)
YANG RUIRUI (CN)
SHAN BIN (CN)
LI RUI (CN)
ZHANG KEKE (CN)
SHI JIANMEI (CN)
LI XUTONG (CN)
Application Number:
PCT/CN2022/135257
Publication Date:
June 15, 2023
Filing Date:
November 30, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/497; C07D403/04; A61K31/501; A61K31/506; A61P35/00; A61P37/02; C07D403/14; C07D407/04; C07D413/04; C07D417/04
Domestic Patent References:
| WO2021035257A1 | 2021-02-25 | |||
| WO2011025706A2 | 2011-03-03 |
Foreign References:
| CN111971045A | 2020-11-20 |
Other References:
DEGTYARENKO ANNA S., SOLNTSEV PAVLO V., KRAUTSCHEID HARALD, RUSANOV EDUARD B., CHERNEGA ALEXANDER N., DOMASEVITCH KONSTANTIN V.: "Copper(i) and silver(i) coordination frameworks involving extended bipyridazine bridges", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 32, no. 11, 1 January 2008 (2008-01-01), GB , pages 1910, XP093071138, ISSN: 1144-0546, DOI: 10.1039/b801231h
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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