Title:
SMO HUMAN ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2023/101438
Kind Code:
A1
Abstract:
The present invention pertains to a novel human antibody or an antigen-binding fragment thereof that recognizes the Smoothened (SMO) protein as an antigen and specifically binds to the SMO protein. The antibody according to the present invention specifically binds to the SMO protein, which is directly involved in major cancer progression processes such as the proliferation, migration, invasion, and metastasis of cancer cells, and blocks the progression of cancer cells, and can thus be advantageously used as a therapeutic agent for various cancers such as colorectal cancer, or resistant cancer, metastatic cancer, or recurrent cancer.
Inventors:
KIM BO RAM (KR)
HUR MINKYU (KR)
LIM HAET NIM (KR)
LEE JISUN (KR)
OH SANG CHEUL (KR)
JUNG SANG TAEK (KR)
HUR MINKYU (KR)
LIM HAET NIM (KR)
LEE JISUN (KR)
OH SANG CHEUL (KR)
JUNG SANG TAEK (KR)
Application Number:
PCT/KR2022/019261
Publication Date:
June 08, 2023
Filing Date:
November 30, 2022
Export Citation:
Assignee:
HEDGEHOG INC (KR)
UNIV KOREA RES & BUS FOUND (KR)
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07K16/28
Foreign References:
| KR20200006948A | 2020-01-21 | |||
| US6136958A | 2000-10-24 | |||
| US20100041663A1 | 2010-02-18 | |||
| US8481680B2 | 2013-07-09 |
Other References:
JENG KUO-SHYANG, SHEEN I-SHYAN, LEU CHUEN-MIIN, TSENG PING-HUI, CHANG CHIUNG-FANG: "The Role of Smoothened in Cancer", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 18, 18 September 2020 (2020-09-18), pages 6863, XP093068781, DOI: 10.3390/ijms21186863
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
Download PDF: