Title:
SMTP-7 DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/171151
Kind Code:
A1
Abstract:
The present disclosure relates to an SMTP-7 derivative and the use thereof. In particular, provided is a compound as represented by formula I or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description.
Inventors:
ZHU LINGJIAN (CN)
YU XIUZHAO (CN)
LIU XIAOWU (CN)
BEN PEIPEI (CN)
CHEN LEI (CN)
KONG XIANGLIN (CN)
HUANG JIAN (CN)
SUN PIAOYANG (CN)
YU XIUZHAO (CN)
LIU XIAOWU (CN)
BEN PEIPEI (CN)
CHEN LEI (CN)
KONG XIANGLIN (CN)
HUANG JIAN (CN)
SUN PIAOYANG (CN)
Application Number:
PCT/CN2022/075740
Publication Date:
August 18, 2022
Filing Date:
February 10, 2022
Export Citation:
Assignee:
SHANGHAI SENHUI MEDICINE CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D519/00; A61K31/407; A61P7/02; A61P9/10
Domestic Patent References:
| WO2020184691A1 | 2020-09-17 | |||
| WO2012115209A1 | 2012-08-30 |
Foreign References:
| CN102115478A | 2011-07-06 | |||
| CN106946910A | 2017-07-14 |
Other References:
SAWADA, H. ET AL.: "SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates", JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, vol. 34, no. 2, 31 December 2014 (2014-12-31), XP055953671, ISSN: 0271-678X, DOI: 10.1038/jcbfm.2013.191
SHIBATA, K. ET AL.: "A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 382, no. 3, 3 August 2010 (2010-08-03), XP019838869, ISSN: 0028-1298
HU, W. M. ET AL.: "SMTP (Stachybotrys microspora triprenyl phenol) enhances clot clearance in a pulmonary embolism model in rats", THROMBOSIS JOURNAL, vol. 10, no. 2, 9 January 2012 (2012-01-09), XP021118694, ISSN: 1477-9560, DOI: 10.1186/1477-9560-10-2
WEIMIN HSHIGEKI O ET AL., ANTIBIOT., vol. 53, no. 3, 2000, pages 241 - 247
SYNLETT, vol. 27, no. 2, 2016, pages 309 - 312
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 39, 2017, pages 13830 - 13836
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 23, 2018, pages 7116 - 7126
J CEREB BLOOD FLOW METAB, vol. 17, no. 2, 1997, pages 123 - 135
SHIBATA, K. ET AL.: "A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 382, no. 3, 3 August 2010 (2010-08-03), XP019838869, ISSN: 0028-1298
HU, W. M. ET AL.: "SMTP (Stachybotrys microspora triprenyl phenol) enhances clot clearance in a pulmonary embolism model in rats", THROMBOSIS JOURNAL, vol. 10, no. 2, 9 January 2012 (2012-01-09), XP021118694, ISSN: 1477-9560, DOI: 10.1186/1477-9560-10-2
WEIMIN HSHIGEKI O ET AL., ANTIBIOT., vol. 53, no. 3, 2000, pages 241 - 247
SYNLETT, vol. 27, no. 2, 2016, pages 309 - 312
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 39, 2017, pages 13830 - 13836
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 23, 2018, pages 7116 - 7126
J CEREB BLOOD FLOW METAB, vol. 17, no. 2, 1997, pages 123 - 135
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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