Title:
SODIUM CHANNEL REGULATORS AND MODULATORS
Document Type and Number:
WIPO Patent Application WO2003016917
Kind Code:
A3
Abstract:
The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound under conditions where the VGSC and the p11 peptide are capable of forming a complex in the absence of the test compound; and measuring an activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC. Compounds identified in such screening methods are proposed for use in the treatment of VGSC-related conditions, for example in the treatment or prevention of pain. Also provided are methods of enhancing the functional expression of a voltage gated sodium channel (VGSC) in a cell comprising the step of increasing the level of p11 in the cell.
Inventors:
OKUSE KENJI (GB)
BAKER MARK (GB)
POON LOUISA (GB)
WOOD JOHN NICHOLAS (GB)
MALIK-HALL MISBAH (GB)
BAKER MARK (GB)
POON LOUISA (GB)
WOOD JOHN NICHOLAS (GB)
MALIK-HALL MISBAH (GB)
Application Number:
PCT/GB2002/003852
Publication Date:
May 30, 2003
Filing Date:
August 20, 2002
Export Citation:
Assignee:
UNIV LONDON (GB)
OKUSE KENJI (GB)
BAKER MARK (GB)
POON LOUISA (GB)
WOOD JOHN NICHOLAS (GB)
MALIK-HALL MISBAH (GB)
OKUSE KENJI (GB)
BAKER MARK (GB)
POON LOUISA (GB)
WOOD JOHN NICHOLAS (GB)
MALIK-HALL MISBAH (GB)
International Classes:
A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P25/02; A61P25/04; A61P29/00; G01N33/50; A61P29/02; A61P43/00; C07K14/47; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/02; G01N33/15; G01N33/566; G01N33/68; (IPC1-7): G01N33/68; C12N5/10; A61P29/02; A61K39/395; C12N15/11; C07K7/06; C07K7/08; C07K14/47
Domestic Patent References:
| WO2001057024A1 | 2001-08-09 | |||
| WO1997001577A1 | 1997-01-16 |
Foreign References:
| US5892018A | 1999-04-06 | |||
| US5990295A | 1999-11-23 |
Other References:
OKUSE KENJI ET AL: "Annexin II light chain regulates sensory neuron-specific sodium channel expression.", NATURE. ENGLAND 6 JUN 2002, vol. 417, no. 6889, 6 June 2002 (2002-06-06), pages 653 - 656, XP001121255, ISSN: 0028-0836
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