Title:
SOLVATE OF INDOLINE SPIRO COMPOUND, AND CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/083164
Kind Code:
A1
Abstract:
Provided are an anisole solvate of an indoline spiro compound represented by formula (1), and a crystal form thereof, a preparation method therefor and the use thereof. The X-ray powder diffraction pattern of the crystal form comprises characteristic peaks at 7.07±0.20° 2θ, as determined by using Cu-Kα radiation. The provided solvate and the crystal form thereof have high purity and good solubility, are beneficial to drug formation, and can also be used for impurity removal and purification of the compound as represented by formula (1).
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Inventors:
LIN DAIZONG (CN)
HUANG QIANG (CN)
SHAO WENBO (CN)
SUN YI (CN)
LOU XIYU (CN)
LIU QINGYIN (CN)
XU XUEYU (CN)
YANG FANGLONG (CN)
WANG SIQIN (CN)
JIN LEI (CN)
HUANG QIANG (CN)
SHAO WENBO (CN)
SUN YI (CN)
LOU XIYU (CN)
LIU QINGYIN (CN)
XU XUEYU (CN)
YANG FANGLONG (CN)
WANG SIQIN (CN)
JIN LEI (CN)
Application Number:
PCT/CN2023/125267
Publication Date:
April 25, 2024
Filing Date:
October 18, 2023
Export Citation:
Assignee:
CHANGCHUN GENESCIENCE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K5/062; A61K31/438; A61P3/00; C07D471/10
Domestic Patent References:
| WO2022228318A1 | 2022-11-03 | |||
| WO2016146712A1 | 2016-09-22 |
Foreign References:
| CN1901908A | 2007-01-24 | |||
| CN102906093A | 2013-01-30 | |||
| CN106008529A | 2016-10-12 | |||
| CN107226816A | 2017-10-03 | |||
| CN1092767A | 1994-09-28 | |||
| CN115010644A | 2022-09-06 |
Attorney, Agent or Firm:
BEIJING DOCVIT LAW FIRM (CN)
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