Title:
SOS1 INHIBITOR AND DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/153748
Kind Code:
A1
Abstract:
The present invention relates to an SOS1 inhibitor and a derivative thereof. A compound, or a pharmaceutically acceptable salt, hydrate, solvate, tautomer, enantiomer, or pharmaceutically acceptable diastereomer thereof of the present invention has an excellent ability to inhibit SOS1 activity, and thus can be advantageously utilized as an agent for preventing, alleviating, or treating a disease caused by abnormal cell growth, wherein the abnormal cell growth disease may include various types of tumor diseases selected from gastric cancer, lung cancer, liver cancer, colorectal cancer, small intestine cancer, pancreatic cancer, brain cancer, bone cancer, melanoma, breast cancer, sclerosing adenosis, uterine cancer, cervical cancer, head and neck cancer, esophageal cancer, thyroid cancer, parathyroid cancer, kidney cancer, sarcoma, prostate cancer, urethral cancer, bladder cancer, leukemia (acute myeloid leukemia), multiple myeloma, hematologic malignancy such as myelodysplastic syndrome, lymphomas such as Hodgkin's disease and non-Hodgkin's lymphoma, or fibroadenomas.
Inventors:
SIM TAE BO (KR)
YOON JEONG HYEOK (KR)
HAN HYE JUNG (KR)
KIM KYU TAE (KR)
NAM KY YOUB (KR)
RYU SEONG SHICK (KR)
SHIN IN JAE (KR)
CHO HAN NA (KR)
KIM NAM KYOUNG (KR)
LEE JI WON (KR)
KIM CHEOL HEE (KR)
YOON JEONG HYEOK (KR)
HAN HYE JUNG (KR)
KIM KYU TAE (KR)
NAM KY YOUB (KR)
RYU SEONG SHICK (KR)
SHIN IN JAE (KR)
CHO HAN NA (KR)
KIM NAM KYOUNG (KR)
LEE JI WON (KR)
KIM CHEOL HEE (KR)
Application Number:
PCT/KR2023/001685
Publication Date:
August 17, 2023
Filing Date:
February 07, 2023
Export Citation:
Assignee:
PHAROS IBIO CO LTD (KR)
International Classes:
C07D239/94; A61K31/517; A61K31/519; A61P35/00; C07D401/12; C07D403/12; C07D409/12; C07D417/12; C07D471/04; C07D495/04
Domestic Patent References:
| WO2021228028A1 | 2021-11-18 | |||
| WO2021130731A1 | 2021-07-01 | |||
| WO2021203768A1 | 2021-10-14 |
Foreign References:
| KR20210146287A | 2021-12-03 |
Other References:
HILLIG ROMAN C., SAUTIER BRICE, SCHROEDER JENS, MOOSMAYER DIETER, HILPMANN ANDRé, STEGMANN CHRISTIAN M., WERBECK NICOLAS D., : "Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 7, 12 February 2019 (2019-02-12), pages 2551 - 2560, XP055841142, ISSN: 0027-8424, DOI: 10.1073/pnas.1812963116
Attorney, Agent or Firm:
PARK, Hyuk (KR)
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