SPERM-SPECIFIC CATION CHANNEL, CATSPER-4, AND USES THEREFOR

WIPO Patent Application WO2004015066

A3

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.

MORAN MAGDALENE M (US)
CHONG JAYHONG A (US)
RAMSEY IAN SCOTT (US)
CLAPHAM DAVID E (US)

PCT/US2003/024359

August 26, 2004

August 04, 2003

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CHILDRENS MEDICAL CENTER (US)
MORAN MAGDALENE M (US)
CHONG JAYHONG A (US)
RAMSEY IAN SCOTT (US)
CLAPHAM DAVID E (US)

C07K14/47; C12N5/02; (IPC1-7): C07H21/02; C07H21/04; C12N15/00; C12N15/09; C12N15/63; C12N15/70; C12N15/74; C12N5/00; C12N5/02; G01N33/53; C12Q1/68

CARLSON A.E. ET AL: "CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm", PNAS, vol. 100, no. 25, 9 December 2003 (2003-12-09), pages 14864 - 14868, XP002977879
QUILL A. ET AL: "A voltage-gated ion channel expressed specifically in spermatozoa", PNAS, vol. 98, no. 22, 23 October 2001 (2001-10-23), pages 12527 - 12531, XP002253116
REN D. ET AL.: "A sperm ion channel required for sperm motility and male fertility", NATURE, vol. 413, 11 October 2001 (2001-10-11), pages 603 - 609, XP002253117

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