SPINAL PROGENITOR CELL FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS, INDUCED DIFFERENTIATION METHOD THEREFOR, AND USE THEREOF

Title:

SPINAL PROGENITOR CELL FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS, INDUCED DIFFERENTIATION METHOD THEREFOR, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/246644

Kind Code:

A1

Abstract:

The present invention provides a spinal progenitor cell for treating amyotrophic lateral sclerosis (ALS). The spinal progenitor cell is represented as at least any two of PAX6+, SOX1+, Nkx6.1+, SOX2+, DBX2+, OLIG2+, PAX3+, or Nkx2.2+, and is represented as PAX7-, and the spinal progenitor cell is obtained by differentiation of a human-induced neural stem cell. Further provided is an induced differentiation method for the spinal progenitor cell. The spinal progenitor cell can be used for preparing a drug or a medical instrument for treating ALS. The spinal progenitor cell of the present invention shows good ALS treatment activity after transplantation, and provides a new treatment article and regimen for ALS treatment.

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Inventors:

CHEN ZHIGUO (CN)
ZHENG TIANQI (CN)

Application Number:

PCT/CN2023/100710

Publication Date:

December 28, 2023

Filing Date:

June 16, 2023

Export Citation:

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Assignee:

WISEHEART MEDICAL VALLEY CO LTD (CN)

International Classes:

C12N5/0797; A61K35/30; A61P21/00; A61P25/00; C12N5/0786

Domestic Patent References:

WO2016103269A1

2016-06-30

Foreign References:

CN115074327A	2022-09-20
CN114214279A	2022-03-22
CN112626023A	2021-04-09

Other References:

XUE-JUN LI, BAO-YANG HU, STEFANIE A. JONES, YING-SHA ZHANG, TIMOTHY LAVAUTE, ZHONG-WEI DU, SU-CHUN ZHANG: "Directed Differentiation of Ventral Spinal Progenitors and Motor Neurons from Human Embryonic Stem Cells by Small Molecules", STEM CELLS, ALPHAMED PRESS, vol. 26, no. 4, 1 April 2008 (2008-04-01), pages 886 - 893, XP055177240, ISSN: 10665099, DOI: 10.1634/stemcells.2007-0620

Attorney, Agent or Firm:

JUN HE LAW OFFICES (CN)

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