SPIRO-ARYL-PHOSPHORUS-OXYGEN COMPOUND AS FOURTH GENERATION OF EGFR KINASE INHIBITOR

Title:

SPIRO-ARYL-PHOSPHORUS-OXYGEN COMPOUND AS FOURTH GENERATION OF EGFR KINASE INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2018/108064

Kind Code:

A1

Abstract:

Disclosed are a fourth generation (T790M/C797S mutation) of an EGFR kinase inhibitor, i.e. a spiro-aryl-phosphorous-oxygen compound, in particular a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof, used for treating cancers.

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Inventors:

WU LINGYUN (CN)
LIU XILE (CN)
DING CHARLES Z (CN)
CHEN SHUHUI (CN)
HU LIHONG (CN)
ZHAO LELE (CN)
PAN WEI (CN)
HU GUOPING (CN)
LI JIAN (CN)

Application Number:

PCT/CN2017/115577

Publication Date:

June 21, 2018

Filing Date:

December 12, 2017

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Assignee:

MEDSHINE DISCOVERY INC (CN)

International Classes:

C07F9/53; A61K31/66; A61P35/00; C07D221/20; C07D471/04; C07D471/10; C07D487/10

Foreign References:

CN102105150A	2011-06-22
CN103501612A	2014-01-08
CN104130265A	2014-11-05

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)

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