Title:
STABILISER FOR RADIOPHARMACEUTICALS
Document Type and Number:
WIPO Patent Application WO2001097862
Kind Code:
A3
Abstract:
The present invention provides an improved stabiliser for radiopharmaceuticals which inhibits impurities from being produced by two kinds of decomposition mechanisms and exhibits such an effect that the shelf life of a radiopharmaceutical after its preparation is prolonged as compared with conventional ones. The improvement comprises a combination of an amino-substituted aromatic carboxylic acid or its salt, ester or amide in combination with a diphosphonic acid or its salt.
Inventors:
STOREY ANTHONY EAMON (GB)
BRAUERS GEORG (GB)
HANAOKA KOICHI (JP)
MINOSAKO YOSHIHITO (JP)
HOMMA KOICHI (JP)
SHIRAKAMI YOSHIFUMI (JP)
BRAUERS GEORG (GB)
HANAOKA KOICHI (JP)
MINOSAKO YOSHIHITO (JP)
HOMMA KOICHI (JP)
SHIRAKAMI YOSHIFUMI (JP)
Application Number:
PCT/GB2001/002652
Publication Date:
August 01, 2002
Filing Date:
June 18, 2001
Export Citation:
Assignee:
AMERSHAM PLC (GB)
NIHON MEDIPHYSICS CO LTD (JP)
STOREY ANTHONY EAMON (GB)
BRAUERS GEORG (GB)
HANAOKA KOICHI (JP)
MINOSAKO YOSHIHITO (JP)
HOMMA KOICHI (JP)
SHIRAKAMI YOSHIFUMI (JP)
NIHON MEDIPHYSICS CO LTD (JP)
STOREY ANTHONY EAMON (GB)
BRAUERS GEORG (GB)
HANAOKA KOICHI (JP)
MINOSAKO YOSHIHITO (JP)
HOMMA KOICHI (JP)
SHIRAKAMI YOSHIFUMI (JP)
International Classes:
A61K47/16; A61K47/18; A61K47/22; A61K47/24; A61K47/02; A61K51/00; A61K51/04; A61P43/00; (IPC1-7): A61K51/12; A61K51/04
Domestic Patent References:
| WO1987001289A1 | 1987-03-12 |
Foreign References:
| EP0508724A1 | 1992-10-14 | |||
| US5093105A | 1992-03-03 | |||
| US4642229A | 1987-02-10 | |||
| US4451451A | 1984-05-29 | |||
| EP0250966A1 | 1988-01-07 |
Other References:
MATHER S J ET AL: "REDUCTION-MEDIATED TECHNETIUM-99M LABELING OF MONOCLONAL ANTIBODIES", JOURNAL OF NUCLEAR MEDICINE, vol. 31, no. 5, 1990, pages 692 - 697, XP002192463, ISSN: 0161-5505
MORALES A. ET AL: "Freeze-dried formulation for the direct 99m-Tc-labeling of ior egf/r3 monoclonal antibody: Equivalence studies", BIOTECNOLOGIA APLICADA, vol. 17, no. 1, January 2000 (2000-01-01) - March 2000 (2000-03-01), pages 39 - 44, XP001053779, ISSN: 0864-4551
SCHOMACKER K ET AL: "Verschiedene 99mTc-Generatoreluate: Auswirkungen auf die radiochemische Reinheit der Markierungsprodukte.", NUKLEARMEDIZIN, FEB 1994, VOL. 33, NO. 1, PAGE(S) 33-9, XP001053778
CLEYNHENS, B. ET AL: "Evaluation of the efficacy of different antioxidants in technetium 99m- methylenediphosphonic acid preparations", NUKLEARMEDIZIN, SUPPL., 1991, VOL. 27, 133-5, XP001064204
HEGGLI D.E. ET AL: "Differences in biodistribution in rats injected with 99m-Tc-MDP preparations with different stabilizing agents", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1988, VOL. 14, NO. 2, PAGE(S) 105-107, XP001053767
GODARD J ET AL: "Traitement de l'oedème cérébral péritumoral par le tétracosactide", LA PRESSE MEDICALE, MAY 15 1993, VOL. 22, NO. 17, PAGE(S) 806-10, XP001053784
MORALES A. ET AL: "Freeze-dried formulation for the direct 99m-Tc-labeling of ior egf/r3 monoclonal antibody: Equivalence studies", BIOTECNOLOGIA APLICADA, vol. 17, no. 1, January 2000 (2000-01-01) - March 2000 (2000-03-01), pages 39 - 44, XP001053779, ISSN: 0864-4551
SCHOMACKER K ET AL: "Verschiedene 99mTc-Generatoreluate: Auswirkungen auf die radiochemische Reinheit der Markierungsprodukte.", NUKLEARMEDIZIN, FEB 1994, VOL. 33, NO. 1, PAGE(S) 33-9, XP001053778
CLEYNHENS, B. ET AL: "Evaluation of the efficacy of different antioxidants in technetium 99m- methylenediphosphonic acid preparations", NUKLEARMEDIZIN, SUPPL., 1991, VOL. 27, 133-5, XP001064204
HEGGLI D.E. ET AL: "Differences in biodistribution in rats injected with 99m-Tc-MDP preparations with different stabilizing agents", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1988, VOL. 14, NO. 2, PAGE(S) 105-107, XP001053767
GODARD J ET AL: "Traitement de l'oedème cérébral péritumoral par le tétracosactide", LA PRESSE MEDICALE, MAY 15 1993, VOL. 22, NO. 17, PAGE(S) 806-10, XP001053784
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