Title:
VITRONECTIN RECEPTOR ANTAGONIST PHARMACEUTICALS
Document Type and Number:
WIPO Patent Application WO2001097861
Kind Code:
A3
Abstract:
The present invention describes novel compounds of the formula:(Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer in combination therapy in a patient. The present invention provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety.
Inventors:
CHEESMAN EDWARD H
BARRETT JOHN A
CARPENTER ALAN P JR
RAJOPADHYE MILIND
SWORIN MICHAEL
BARRETT JOHN A
CARPENTER ALAN P JR
RAJOPADHYE MILIND
SWORIN MICHAEL
Application Number:
PCT/US2001/020203
Publication Date:
February 27, 2003
Filing Date:
June 21, 2001
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB PHARMA CO (US)
International Classes:
A61K31/551; A61K51/04; A61K51/08; A61P35/00; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07F9/645; C07F9/6558; C07K5/02; C07K5/06; C07K5/072; C07K5/083; C07K7/02; C07K7/52; C07K14/78; A61K38/00; (IPC1-7): A61K41/00; A61K51/04; A61P35/00
Domestic Patent References:
| WO1999005107A1 | 1999-02-04 | |||
| WO1996000574A1 | 1996-01-11 | |||
| WO1999059640A2 | 1999-11-25 | |||
| WO2000035887A2 | 2000-06-22 | |||
| WO2001097860A2 | 2001-12-27 | |||
| WO2001098294A2 | 2001-12-27 | |||
| WO2002004030A2 | 2002-01-17 | |||
| WO2001097848A2 | 2001-12-27 |
Other References:
KAWAI KAZUYOSHI ET AL: "Enhancement of anticancer effects of radiation and conventional anticancer agents by a quinolinone derivative, vesnarinone: Studies on human gastric cancer tissue xenografts in nude mice.", ANTICANCER RESEARCH, vol. 18, no. 1A, January 1998 (1998-01-01), pages 405 - 412, XP008009504, ISSN: 0250-7005
OKARO, M. C. (1) ET AL: "Pk11195, a mitochondrial benzodiazepine receptor antagonist radiosensitizes bcl-XL and mcl-1 expressing cholangiocarcinoma to apoptosis.", BRITISH JOURNAL OF CANCER, (JULY, 2000) VOL. 83, NO. SUPPLEMENT 1, PP. 22 PRINT. MEETING INFO.: MEETING OF THE BRITISH CANCER RESEARCH BRIGHTON, UK JULY 09-12, 2000, XP008010828
HARRIS T D ET AL: "Radiolabeled indazole-based alphavbeta3 antagonists as potential tumor imaging agents.", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 44, no. Supplement 1, May 2001 (2001-05-01), Fourteenth International Symposium on Radiopharmaceutical Chemistry;Interlaken, Switzerland; June 10-15, 2001, pages S60 - S62, XP008009503, ISSN: 0362-4803
OKARO, M. C. (1) ET AL: "Pk11195, a mitochondrial benzodiazepine receptor antagonist radiosensitizes bcl-XL and mcl-1 expressing cholangiocarcinoma to apoptosis.", BRITISH JOURNAL OF CANCER, (JULY, 2000) VOL. 83, NO. SUPPLEMENT 1, PP. 22 PRINT. MEETING INFO.: MEETING OF THE BRITISH CANCER RESEARCH BRIGHTON, UK JULY 09-12, 2000, XP008010828
HARRIS T D ET AL: "Radiolabeled indazole-based alphavbeta3 antagonists as potential tumor imaging agents.", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 44, no. Supplement 1, May 2001 (2001-05-01), Fourteenth International Symposium on Radiopharmaceutical Chemistry;Interlaken, Switzerland; June 10-15, 2001, pages S60 - S62, XP008009503, ISSN: 0362-4803
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