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Title:
SUBCUTANEOUS DELIVERY OF MULTIMERIC OLIGONUCLEOTIDES WITH ENHANCED BIOACTIVITY
Document Type and Number:
WIPO Patent Application WO/2021/021959
Kind Code:
A3
Abstract:
The present disclosure relates to methods of administering, subcutaneously, to a subject, multimeric oligonucleotides having monomeric subunits joined by covalent linkers. The multimeric oligonucleotides have a molecular weight and/or size configured to increase in vivo activity of one or more subunits within the multimeric oligonucleotide relative to in vivo activity of the same subunit when administered in monomeric form of at least about 45 kD and other characteristics, such that their clearance due to glomerular filtration is reduced. The present disclosure also relates to such multimeric oligonucleotides and methods of synthesizing such multimeric oligonucleotides.

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Inventors:
BROWN JONATHAN MILES (US)
NEUMAN KRISTIN K H (US)
Application Number:
PCT/US2020/044110
Publication Date:
March 04, 2021
Filing Date:
July 29, 2020
Export Citation:
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Assignee:
MPEG LA L L C (US)
International Classes:
C12N15/113; C12N15/11
Foreign References:
US20190085331A12019-03-21
US20170204408A92017-07-20
US20150315585A12015-11-05
Attorney, Agent or Firm:
MALLON, Joseph J. (US)
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