遺伝子改変細胞及びその作製方法 - Kissei Pharmaceutical Co., Ltd.

Title:

遺伝子改変細胞及びその作製方法

Document Type and Number:

Japanese Patent JP6698854

Kind Code:

B2

Abstract:

Production of a chimeric antigen receptor (CAR) expressing cell having excellent target cytotoxicity. Provided is a genetically modified cell comprising, introduced thereinto, a polynucleotide encoding a chimeric antigen receptor (CAR) protein having a target binding domain that specifically binds to a human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor, a transmembrane domain and an intracellular signaling domain.

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Inventors:

Nakazawa Yozo
Kazuyuki Matsuda
Shigeru Nakano

Application Number:

JP2018539204A

Publication Date:

May 27, 2020

Filing Date:

September 15, 2017

Export Citation:

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Assignee:

Kissei Pharmaceutical Co., Ltd.
Shinshu University

International Classes:

C12N15/63; A61K31/7088; A61K35/12; A61K48/00; A61P35/02; C12N5/10; C12N15/113; C12N15/12; C12N15/13; C12N15/62

Domestic Patent References:

JP63502795A

Foreign References:

WO2017061615A1
WO2013051718A1
WO2014127261A1
WO2015090229A1
WO2015124715A1
WO2015066262A1

Attorney, Agent or Firm:

Hiraki International Patent Office

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