SUBSTITUTED 6- (PYRIMIDIN-4-YL) QUINOLINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS

Title:

SUBSTITUTED 6- (PYRIMIDIN-4-YL) QUINOLINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2023/208173

Kind Code:

A1

Abstract:

This disclosure provides compounds containing 6- (pyrimidin-4-yl) quinoline structure, the use thereof for selectively inhibiting the activity of CDK4, and pharmaceutical compositions comprising the compounds as treatment of various diseases including cancer.

Inventors:

LI JING (CN)
XU WENQING (CN)
WANG ZHIWEI (CN)

Application Number:

PCT/CN2023/091483

Publication Date:

November 02, 2023

Filing Date:

April 28, 2023

Export Citation:

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Assignee:

BEIGENE LTD (GB)
LI JING (CN)

International Classes:

C07D405/14; A61K31/5377; A61P35/00; C07D401/04; C07D401/14; C07D405/04

Domestic Patent References:

WO2009017838A2	2009-02-05
WO2008124085A2	2008-10-16

Foreign References:

US20090298830A1	2009-12-03
US20070117818A1	2007-05-24

Attorney, Agent or Firm:

WU, FENG & ZHANG (CN)

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