SUBSTITUTED 7- (PYRIMIDIN-4-YL) QUINOLIN-4 (1H) -ONE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS

Title:

SUBSTITUTED 7- (PYRIMIDIN-4-YL) QUINOLIN-4 (1H) -ONE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2023/208172

Kind Code:

A1

Abstract:

Provided are compounds containing 7-(pyrimidin-4-yl) quinolin-4(1H)-one structure of Formula (I), the use thereof for selectively inhibiting the activity of CDK4, and pharmaceutical compositions comprising the compounds as treatment of various diseases including cancer.

Inventors:

LI JING (CN)
XU WENQING (CN)
WANG ZHIWEI (CN)

Application Number:

PCT/CN2023/091482

Publication Date:

November 02, 2023

Filing Date:

April 28, 2023

Export Citation:

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Assignee:

BEIGENE LTD (GB)
LI JING (CN)

International Classes:

C07D471/04; A61K31/435; A61K31/47; A61P35/00; C07D215/56; C07D401/14; C07D405/04

Domestic Patent References:

WO2022236256A1	2022-11-10
WO2013029548A1	2013-03-07
WO2019161224A1	2019-08-22
WO2021030623A1	2021-02-18

Foreign References:

EP0343398A2	1989-11-29
US6080757A	2000-06-27

Attorney, Agent or Firm:

WU , FENG & ZHANG (CN)

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