SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Title:

SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Document Type and Number:

WIPO Patent Application WO/2011/022509

Kind Code:

A3

Abstract:

Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

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Inventors:

HOWBERT JAMES JEFFRY (US)
DIETSCH GREGORY (US)
HERSHBERG ROBERT (US)
BURGESS LAURENCE E (US)
DOHERTY GEORGE A (US)
EARY C TODD (US)
GRONEBERG ROBERT D (US)
JONES ZACHARY (US)

Application Number:

PCT/US2010/045935

Publication Date:

June 16, 2011

Filing Date:

August 18, 2010

Export Citation:

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Assignee:

VENTIRX PHARMACEUTICALS INC (US)
ARRAY BIOPHARMA INC (US)
HOWBERT JAMES JEFFRY (US)
DIETSCH GREGORY (US)
HERSHBERG ROBERT (US)
BURGESS LAURENCE E (US)
DOHERTY GEORGE A (US)
EARY C TODD (US)
GRONEBERG ROBERT D (US)
JONES ZACHARY (US)

International Classes:

C07D403/10; A61K31/4025; A61K31/55; A61P31/00; A61P35/00; C07D223/14; C07D401/14; C07D403/14

Foreign References:

US20080234251A1	2008-09-25
US20020128208A1	2002-09-12

Other References: