SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

Title:

SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

Document Type and Number:

WIPO Patent Application WO2006138510

Kind Code:

B1

Abstract:

The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of a7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on a7 nAChRs in a mammal by administering an effective amount of a compound of Formula (I).

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Inventors:

HOGENKAMP DERK J (US)
JOHNSTONE TIMOTHY B C (US)
GEE KELVIN W (US)

Application Number:

PCT/US2006/023398

Publication Date:

March 01, 2007

Filing Date:

June 15, 2006

Export Citation:

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Assignee:

UNIV CALIFORNIA (US)
HOGENKAMP DERK J (US)
JOHNSTONE TIMOTHY B C (US)
GEE KELVIN W (US)

International Classes:

C07C221/00; A61K31/41; A61K31/435; A61P25/00; C07D213/50; C07D213/56; C07D257/04; C07D261/08; C07D261/14; C07D413/12

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