SUBSTITUTED HETEROCYCLIC COMPOUND CONTAINING α-KETONE FRAMEWORK, AND USE THEREOF

Title:

SUBSTITUTED HETEROCYCLIC COMPOUND CONTAINING α-KETONE FRAMEWORK, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/046055

Kind Code:

A1

Abstract:

Disclosed in the present invention are a substituted heterocyclic compound containing an α-ketone framework, and the use thereof, which relate to the field of medicinal chemistry. Specifically disclosed are a substituted heterocyclic compound containing an α-ketone framework, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing these compounds, and the medical use thereof, and in particular, the use thereof as a fatty acid amide hydrolase (FAAH) inhibitor in the preparation of a drug for preventing or treating FAAH-related diseases, comprising inflammatory diseases, rheumatoid arthritis, hepatitis, hepatic fibrosis, autoimmune disease, pain, depression, pain and depression comorbidity, autism, social anxiety disorder, Tourette's syndrome, neurodegenerative diseases, anxiety and post-traumatic stress disorder (PTSD), cannabinoid use disorders, drug withdrawal and anti-tumor treatment.

Inventors:

WANG JINXIN (CN)
LI LILI (CN)
MENG TAO (CN)
SHANG YANGUO (CN)
HAO QINGJING (CN)
JIA YIHE (CN)

Application Number:

PCT/CN2022/120795

Publication Date:

March 30, 2023

Filing Date:

September 23, 2022

Export Citation:

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Assignee:

UNIV CHINA PHARMA (CN)

International Classes:

C07D401/14; A61K31/454; A61K31/4545; A61K31/4709; A61P1/16; A61P19/02; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/36; A61P29/00; A61P31/20; A61P35/00; A61P37/00; C07D405/14; C07D413/14; C07D417/14

Domestic Patent References:

WO2007140005A2	2007-12-06
WO1992006086A1	1992-04-16

Foreign References:

CN110804048A	2020-02-18
US20050256159A1	2005-11-17

Other References:

ZHAO DONG-SHENG, WANG HAI-YAN, LIAN ZHI-HUI, HAN DA-XIONG, JIN XIN: "Pharmacophore modeling and virtual screening for the discovery of new fatty acid amide hydrolase inhibitors", ACTA PHARMACEUTICA SINICA B, vol. 1, no. 1, 1 June 2011 (2011-06-01), pages 27 - 35, XP093053639, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2011.04.003

Attorney, Agent or Firm:

NANJING TIANHUA PATENT AGENT CO., LTD. (CN)

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