Title:
SUBSTITUTED HYDANTOIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2024/017178
Kind Code:
A1
Abstract:
Provided herein are substituted hydantoin compounds, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a viral infection.
Inventors:
WANG GUOQIANG (CN)
QIU YAOLING (CN)
CHEN PING (CN)
LI JUN (CN)
LI MING (CN)
CAI ZHENWEI (CN)
MA XIAOCHU (CN)
TANG XINXING (CN)
QIU YAOLING (CN)
CHEN PING (CN)
LI JUN (CN)
LI MING (CN)
CAI ZHENWEI (CN)
MA XIAOCHU (CN)
TANG XINXING (CN)
Application Number:
PCT/CN2023/107653
Publication Date:
January 25, 2024
Filing Date:
July 17, 2023
Export Citation:
Assignee:
AVITAR BIOSCIENCES INC (CN)
WANG GUOQIANG (CN)
QIU YAOLING (CN)
CHEN PING (CN)
LI JUN (CN)
LI MING (CN)
CAI ZHENWEI (CN)
MA XIAOCHU (CN)
TANG XINXING (CN)
WANG GUOQIANG (CN)
QIU YAOLING (CN)
CHEN PING (CN)
LI JUN (CN)
LI MING (CN)
CAI ZHENWEI (CN)
MA XIAOCHU (CN)
TANG XINXING (CN)
International Classes:
C07D401/14; A61K31/4439; A61P31/14; C07D401/04; C07D403/04; C07D403/14; C07D487/10
Domestic Patent References:
| WO2022229458A1 | 2022-11-03 | |||
| WO2021176088A1 | 2021-09-10 |
Foreign References:
| CN115894443A | 2023-04-04 | |||
| US20190382355A1 | 2019-12-19 |
Other References:
LUTTENS, ANDREAS, ET AL.: "Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 144, no. 7, 10 February 2022 (2022-02-10), XP055938395, DOI: 10.1021/jacs.1c08402
DATABASE Registry 31 January 2019 (2019-01-31), ANONYMOUS : " 5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[[4-(methylsulfonyl)phenyl]methyl]-2-phenyl- (CA INDEX NAME)", XP093131942, retrieved from STNext Database accession no. 2263984-67-2
DATABASE Registry 1 February 2019 (2019-02-01), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-2-phenyl- (CA INDEX NAME)", XP093131957, retrieved from STNext Database accession no. 2264243-49-2
DATABASE Registry 18 February 2022 (2022-02-18), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 2-(2-chlorophenyl)-7-(5-methoxy-3-pyridinyl)- (CA INDEX NAME)5", XP093131960, Database accession no. 2759443-88-2
DATABASE Registry 28 June 2022 (2022-06-28), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[(5-acetyl-2-methoxyphenyl)methyl]-2-phenyl- (CA INDEX NAME)", XP093131966, retrieved from STNext Database accession no. 2780067-14-1
DATABASE Registry 12 July 2022 (2022-07-12), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[(3-nitrophenyl)methyl]-2-phenyl- (CA INDEX NAME)", XP093131969, Database accession no. 2789207-83-4
DATABASE Registry 31 January 2019 (2019-01-31), ANONYMOUS : " 5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[[4-(methylsulfonyl)phenyl]methyl]-2-phenyl- (CA INDEX NAME)", XP093131942, retrieved from STNext Database accession no. 2263984-67-2
DATABASE Registry 1 February 2019 (2019-02-01), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-2-phenyl- (CA INDEX NAME)", XP093131957, retrieved from STNext Database accession no. 2264243-49-2
DATABASE Registry 18 February 2022 (2022-02-18), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 2-(2-chlorophenyl)-7-(5-methoxy-3-pyridinyl)- (CA INDEX NAME)5", XP093131960, Database accession no. 2759443-88-2
DATABASE Registry 28 June 2022 (2022-06-28), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[(5-acetyl-2-methoxyphenyl)methyl]-2-phenyl- (CA INDEX NAME)", XP093131966, retrieved from STNext Database accession no. 2780067-14-1
DATABASE Registry 12 July 2022 (2022-07-12), ANONYMOUS: "5,7-Diazaspiro[3.4]octane-6,8-dione, 7-[(3-nitrophenyl)methyl]-2-phenyl- (CA INDEX NAME)", XP093131969, Database accession no. 2789207-83-4
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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