Title:
SUBSTITUTED PYRROLIDINE COMPOUND AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2021/218992
Kind Code:
A1
Abstract:
Disclosed are a substituted pyrrolidine compound and the use thereof in medicine. In particular, disclosed are a substituted pyrrolidine compound or a stereoisomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt thereof or a prodrug thereof, and a pharmaceutical composition containing the above-mentioned compound. Also disclosed is the use of the above-mentioned compound or the pharmaceutical composition thereof in the preparation of a drug, the drug being used to treat PDE4-related diseases, such as atopic dermatitis (AD) or chronic obstructive pulmonary disease (COPD).
Inventors:
LIU BING (CN)
YU TIANZHU (CN)
ZHANG SHIGUO (CN)
ZHANG YINGJUN (CN)
YU TIANZHU (CN)
ZHANG SHIGUO (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2021/090489
Publication Date:
November 04, 2021
Filing Date:
April 28, 2021
Export Citation:
Assignee:
DONGGUAN HEC NEW DRUG R&D CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D207/12; A61K31/40; A61P29/00; C07D207/36
Domestic Patent References:
| WO2010075086A2 | 2010-07-01 |
Foreign References:
| CN1434797A | 2003-08-06 | |||
| CN1434813A | 2003-08-06 | |||
| CN101166737A | 2008-04-23 |
Other References:
ACOSTA PAOLA, BECERRA DIANA, GOUDEDRANCHE SÉBASTIEN, QUIROGA JAIRO, CONSTANTIEUX THIERRY, BONNE DAMIEN, RODRIGUEZ JEAN: "Exploiting the Reactivity of 1,2-Ketoamides: Enantioselective Synthesis of Functionalized Pyrrolidines and Pyrrolo-1,4-benzodiazepine-2,5-diones", SYNLETT, GEORG THIEME VERLAG, DE, vol. 26, no. 11, 1 January 2015 (2015-01-01), DE , pages 1591 - 1595, XP055861778, ISSN: 0936-5214, DOI: 10.1055/s-0034-1378711
XU YINGJIE, MATSUNAGA SHIGEKI, SHIBASAKI MASAKATSU: "syn -Selective Catalytic Asymmetric 1,4-Addition of α-Ketoanilides to Nitroalkenes under Dinuclear Nickel Catalysis", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 14, 16 July 2010 (2010-07-16), US , pages 3246 - 3249, XP055861779, ISSN: 1523-7060, DOI: 10.1021/ol101185p
XU YINGJIE, MATSUNAGA SHIGEKI, SHIBASAKI MASAKATSU: "syn -Selective Catalytic Asymmetric 1,4-Addition of α-Ketoanilides to Nitroalkenes under Dinuclear Nickel Catalysis", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 14, 16 July 2010 (2010-07-16), US , pages 3246 - 3249, XP055861779, ISSN: 1523-7060, DOI: 10.1021/ol101185p
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