Title:
SUBSTITUTED UREA AND ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO1995009619
Kind Code:
A3
Abstract:
The use of an N-substituted urea derivative for the manufacture of a medicament for the treatment of a condition where there is an advantage in inhibiting the NO synthase enzyme, in particular cerebral ischemia, and pharmaceutical formulations therefor are disclosed. Novel N-substituted urea derivatives and processes for the preparation thereof are also described.
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Inventors:
OPLINGER JEFFREY ALAN (US)
SHEARER BARRY GEORGE (US)
BIGHAM ERIC CLEVELAND (US)
FURFINE ERIC STEVEN (US)
GARVEY EDWARD PATRICK (US)
SHEARER BARRY GEORGE (US)
BIGHAM ERIC CLEVELAND (US)
FURFINE ERIC STEVEN (US)
GARVEY EDWARD PATRICK (US)
Application Number:
PCT/GB1994/002138
Publication Date:
June 15, 1995
Filing Date:
October 03, 1994
Export Citation:
Assignee:
WELLCOME FOUND (GB)
OPLINGER JEFFREY ALAN (GB)
SHEARER BARRY GEORGE (GB)
BIGHAM ERIC CLEVELAND (GB)
FURFINE ERIC STEVEN (GB)
GARVEY EDWARD PATRICK (GB)
OPLINGER JEFFREY ALAN (GB)
SHEARER BARRY GEORGE (GB)
BIGHAM ERIC CLEVELAND (GB)
FURFINE ERIC STEVEN (GB)
GARVEY EDWARD PATRICK (GB)
International Classes:
C07D277/20; A61K31/00; A61K31/13; A61K31/135; A61K31/155; A61K31/16; A61K31/165; A61K31/195; A61K31/215; A61K31/425; A61K31/426; A61K31/44; A61P3/00; A61P9/00; A61P9/10; A61P25/28; A61P43/00; C07C275/16; C07C275/26; C07C275/28; C07C275/70; C07C281/06; C07C335/30; C07C335/32; C07D213/75; C07D277/18; C07D277/42; (IPC1-7): A61K31/00; A61K31/155; A61K31/425; A61K31/44
Foreign References:
| EP0446699A1 | 1991-09-18 | |||
| EP0411615A1 | 1991-02-06 | |||
| EP0392802A2 | 1990-10-17 | |||
| FR1532212A | 1968-07-12 | |||
| GB1178242A | 1970-01-21 | |||
| EP0202157A1 | 1986-11-20 | |||
| NL7703011A | 1977-09-21 |
Other References:
DATABASE WPI Week 9238, Derwent World Patents Index; AN 92-315914
MANLEY, P.W. ET AL: "STRUCTURE ACTIVITY RELATIONSHIPS OF POTASSIUM CHANNEL OPENING IN PINACIDIL-TYPE CYANOGUANIDINES, NITROETHENEDIAMINES, THIOUREAS AND UREAS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, 1992, pages 2327 - 2340
RASMUSSEN, C.R. ET AL: "A VERSATILE SYNTHESIS OF NOVEL N,N,N'-TRISUBSTITUTED GUANIDINES", SYNTHESIS, vol. 6, June 1988 (1988-06-01), pages 460 - 466
DAWSON, V.L. ET AL: "NITRIC OXIDE MEDIATES GLUTAMATE TOXICITY IN PRIMARY CORTICAL CULTURES", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES USA, vol. 88, July 1991 (1991-07-01), pages 6368 - 6371
MANLEY, P.W. ET AL: "STRUCTURE ACTIVITY RELATIONSHIPS OF POTASSIUM CHANNEL OPENING IN PINACIDIL-TYPE CYANOGUANIDINES, NITROETHENEDIAMINES, THIOUREAS AND UREAS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, 1992, pages 2327 - 2340
RASMUSSEN, C.R. ET AL: "A VERSATILE SYNTHESIS OF NOVEL N,N,N'-TRISUBSTITUTED GUANIDINES", SYNTHESIS, vol. 6, June 1988 (1988-06-01), pages 460 - 466
DAWSON, V.L. ET AL: "NITRIC OXIDE MEDIATES GLUTAMATE TOXICITY IN PRIMARY CORTICAL CULTURES", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES USA, vol. 88, July 1991 (1991-07-01), pages 6368 - 6371
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