Title:
SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002078679
Kind Code:
A3
Abstract:
Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison. Formula (I), wherein -J- is selected from the group consisting of (A) and (B). A compound of formula (II) for use as medicament. A compound of formula (III).
More Like This:
| WO/2022/011084 | OXOPYRROLIDINE FPR2 AGONISTS |
| JP2014012706 | COMPOUND HAVING ANTICANCER ACTIVITY |
| WO/2014/021281 | PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND |
Inventors:
JENSEN PETER BUHL (DK)
SOEKILDE BIRGITTE (DK)
CARSTENSEN ELISABETH VANG (DK)
LANGER SEPPO W (DK)
CREIGHTON ANDREW (GB)
SEHESTED MAXVELL (DK)
JENSEN LARS HOELLUND (DK)
SOEKILDE BIRGITTE (DK)
CARSTENSEN ELISABETH VANG (DK)
LANGER SEPPO W (DK)
CREIGHTON ANDREW (GB)
SEHESTED MAXVELL (DK)
JENSEN LARS HOELLUND (DK)
Application Number:
PCT/DK2002/000213
Publication Date:
December 19, 2002
Filing Date:
March 27, 2002
Export Citation:
Assignee:
TOPO TARGET APS (DK)
JENSEN PETER BUHL (DK)
SOEKILDE BIRGITTE (DK)
CARSTENSEN ELISABETH VANG (DK)
LANGER SEPPO W (DK)
CREIGHTON ANDREW (GB)
SEHESTED MAXVELL (DK)
JENSEN LARS HOELLUND (DK)
JENSEN PETER BUHL (DK)
SOEKILDE BIRGITTE (DK)
CARSTENSEN ELISABETH VANG (DK)
LANGER SEPPO W (DK)
CREIGHTON ANDREW (GB)
SEHESTED MAXVELL (DK)
JENSEN LARS HOELLUND (DK)
International Classes:
A61K31/4015; C07D207/416; C07D207/40; (IPC1-7): C12N9/90; C12N15/10; C07D207/40; A61K31/40; C07D207/44; C07D207/448
Domestic Patent References:
| WO2001087307A2 | 2001-11-22 | |||
| WO2000054782A1 | 2000-09-21 | |||
| WO2000021927A2 | 2000-04-20 | |||
| WO1997034980A1 | 1997-09-25 |
Foreign References:
| US20020035090A1 | 2002-03-21 | |||
| EP0540956A1 | 1993-05-12 | |||
| DE19838506A1 | 1999-11-11 |
Other References:
JENSEN L H ET AL: "Maleimide is a potent inhibitor of topoisomerase II in vitro and in vivo: A new mode of catalytic inhibition.", MOLECULAR PHARMACOLOGY, vol. 61, no. 5, 2002, pages 1235 - 1243, XP002902553
SALMON L ET AL: "A general approach to the synthesis of polyamine linked-monoindolylmaleimides, a new series of trypanothione reductase inhibitors.", CHEM. PHARM. BULL., vol. 46, no. 4, 1998, pages 707 - 710, XP002902554
PRUDHOMME M: "Indolocarbazoles as anti-cancer agents.", CURRENT PHARMACEUTICAL DESIGN, vol. 3, no. 3, 1997, pages 265 - 290, XP002902555
HE M ET AL: "Design and synthesis of new leads for PKC bisubstrate inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 24, 1994, pages 2845 - 2850, XP002902556
HASINOFF B B ET AL: "Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site.", MOLECULAR PHARMACOLOGY, vol. 52, 1997, pages 839 - 845, XP002902557
ANIZON F ET AL: "Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 21, 1997, pages 3456 - 3465, XP002902558
SALMON L ET AL: "A general approach to the synthesis of polyamine linked-monoindolylmaleimides, a new series of trypanothione reductase inhibitors.", CHEM. PHARM. BULL., vol. 46, no. 4, 1998, pages 707 - 710, XP002902554
PRUDHOMME M: "Indolocarbazoles as anti-cancer agents.", CURRENT PHARMACEUTICAL DESIGN, vol. 3, no. 3, 1997, pages 265 - 290, XP002902555
HE M ET AL: "Design and synthesis of new leads for PKC bisubstrate inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 24, 1994, pages 2845 - 2850, XP002902556
HASINOFF B B ET AL: "Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site.", MOLECULAR PHARMACOLOGY, vol. 52, 1997, pages 839 - 845, XP002902557
ANIZON F ET AL: "Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 21, 1997, pages 3456 - 3465, XP002902558
Download PDF: